XU Guifang,PENG Yong,CHEN Yong. Detection and correlation study of IL-37, IL-1β and IL-18 in gout patients[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2014, 44(5): 370-.
Abstract：Objective: To determine levels of interleukin-37 (IL-37), IL-1β and IL-18 in serum of patients with gout at difference stages, and to explore the role of IL-37 in the pathogenesis of gout. Methods: The levels of IL-37, IL-1β and IL-18 in 20 patients with gout, 20 patients with hyperuricemia and 20 healthy controls were detected wtih ELISA, the changes and correlations in different groups were analyzed. Results: Gout group in acute attack stage IL-1β and IL-18 levels was significantly higher than those in complete remission period (P<0.05), while the IL-37 level was only slightly higher than that of complete remission period (P>0.05). IL-37, IL-1β and IL-18 in gout group at acute attack stage were significantly higher than that in the hyperuricemia group and healthy control group (P<0.05). The higher expressions of IL-37 in complete remission period were detected and compared with the hyperuricemia group and healthy control group, whereas there was no difference in IL-1β and IL-18 levels (P>0.05). The level of serum IL-37 in gout group at acute attack stage, was positively correlated with ESR, CRP, IL-1β and IL-18 (P<0.01). Conclusion: IL-37 as an inhibiting inflammation factor probably takes part in the process of inflammatory respense of gout.
