LE Yajuan,SHEN Yue,CAI Lili, et al. Serum obestatin and nesfatin-1 levels in patients with first episode schizophrenia and their clinical significance[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2024, 54(1): 25-30.
Abstract：Objective: To explore the relationship between serum obestatin and nesfatin-1 levels with cognitive function in patients with first-episode schizophrenia. Methods: A total of 98 patients diagnosed with first-episode schizophrenia who were admitted to Huzhou Third People’s Hospital from June 2018 to June 2021 were assigned as the patient group, and 102 healthy volunteers in the same period were selected as the control group. The serum levels of Obestatin and nesfatin-1 in patients with first-episode schizophrenia were detected by enzyme-linked immunosorbent assay (ELISA). Clinical symptoms were assessed using the positive and negative syndrome scale (PANSS), the trail-making test (TMT), brief visuospatial memory test-revised (BVMT-R),Hopkins verbal learning test-revised (HVLT-R), brief assessment of cognition in schizophrenia-symbol coding (BACS SC), neuropsychological assessment battery (NAB), continuous performance test-identical pairs (CPT-IP) in the MATRICS consensus cognitive battery (MCCB) were used to evaluate the cognitive function of patients. Results: The serum nesfatin-1 level and TMT score in the patient group were obviously higher than those in the control group, the obestatin level, BVMT-R, HVLT-R, BACS SC, NAB and CPT-IP scores were obviously lower than those in the control group (P<0.05). Pearson’s correlation analysis showed that the expression of nesfatin-1 in the serum of patients with first-episode schizophrenia was obviously positively correlated with the total score of PANSS (r=0.486, P<0.05); the expression of obestatin was obviously negatively correlated with the total score of PANSS (r=-0.422, P<0.05); the level of serum nesfatin-1 was negatively correlated with HVLTR and NAB scores (r=-0.501, -0.545, P<0.05), and the level of obestatin was positively correlated with HVLTR and NAB scores (r=0.435, 0.491, P<0.05). Multivariate logistic regression analysis showed that NAB score (OR=1.541, 95%CI=1.131-2.100, P=0.006), obestatin (OR=1.713, 95%CI=1.247-2.353, P=0.001) and nesfatin-1 levels (OR=1.647, 95%CI=1.213-2.236, P=0.001) were the factors affecting the occurrence of first-episode schizophrenia. Conclusion: The serum levels of obestatin expression was significantly decreased and nesfatin-1 expression was significantly increased in patients with first-episode schizophrenia, which was closely related to the cognitive functions of the patients.
