Hyperuricemia and type 2 diabetes mellitus: Studies on recent advances from clinical perspectives to molecular mechanisms
ZHANG Haohan1, ZHANG Yihan2, XU Huanbai2
1.The Second School of Medicine,Wenzhou Medical University, Wenzhou 325035, China; 2.Department of Endocrinology and Metabolism,Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China
ZHANG Haohan,ZHANG Yihan,XU Huanbai. Hyperuricemia and type 2 diabetes mellitus: Studies on recent advances from clinical perspectives to molecular mechanisms[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2023, 53(11): 939-942.
Abstract：In recent years, the incidence rate of hyperuricemia (HUA) combined with type 2 diabetes(T2DM) has increased year by year. This article reviews the clinical characteristics of HUA combined with T2DM and its possible mechanisms. Clinically, HUA combined with T2DM is more prone to complications such as renal function damage and an increased risk of death; it is more likely to develop in women; perirenal and perirenal fat thickness are both risk factors. Its possible molecular mechanisms include genetic mutation sites,immune inflammation mechanisms, signaling pathways, and others. This study provides a new perspective for the treatment of HUA combined with T2DM by using a new molecular mechanism as entry point.
