YE Junxia,ZHANG Jianbing. The application of ciprofol combined with sufentanil for deep sedation in fiberoptic bronchoscopy[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2023, 53(10): 830-833,838.
Abstract：Objective: To investigate the efficacy and safety of intravenous anesthesia of ciprofol combined with sufentanil for deep sedation in fiberoptic bronchoscopy. Methods: A total of 60 patients who received fiberoptic bronchoscopy in Lishui Hospital of Traditional Chinese Medicine between January 2021 and March 2023 were selected and divided into ciprofol group and propofol group by random number table method (n=30).The ciprofol group (Group H) was given 0.1 μg/kg of sufentanil and 0.4 mg/kg of ciprofol successively, and the propofol group (Group B) was given 0.1 μg/kg of sufentanil and 1-2 mg/kg of propofol successively. The heart rate (HR), mean arterial pressure (MAP), and finger pulse oxygen saturation (SpO2) before examination (T0),as the fiberoptic bronchoscope entering the glottis (T1) and immediately after bronchoscopy (T3), as well as the onset time of anesthesia, recovery time, exit time, bronchoscopy time, number of assisted ventilation times, and incidence of adverse events, were monitored and recorded respectively. Results: As compared with T0, there was statistical significance (P<0.05) between Group H and Group B in decrease of MAP at T1 and T2. There was statistical significance (P<0.05) between Group H and Group B in degree of SpO2 decline and incidence of respiratory at T1 and T2, as compared with T0 and the decline degree of MAP and SpO2 at T1 and T2 in Group H was significantly lower than in group B, with statistical significance (P<0.05). However, there was no statistical significance (P>0.05) between the two groups in exit time and examination time. The incidence of respiratory depression, incidence of adverse events, and the number of assisted ventilation times in Group H were lower than in Group B, with statistical significance (P<0.05) between the two groups. Conclusion: Under the same titer,ciprofol is equivalent to propofol combined with sufentanil in anesthetic effect for fiberoptic bronchoscopy.Ciprofol combined with sufentanil is safe when used for anesthesia in fiberoptic bronchoscopy in that it has slight effect on the patient’s breathing and blood pressure, stable hemodynamics and less adverse reaction.
