The impact of obstructive sleep apnea hypopnea syndrome on cognitive processing in children
JIANG Changcan1, WANG Jie1, CHEN Xu2, LI Zhijie2, YU Chenyi2.
1.Department of Otolaryngology, the Second Affiliated Hospital & Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou 325027, China;2.Department of Pediatric Sleep Medicine, the Second Affiliated Hospital & Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou 325027, China
JIANG Changcan,WANG Jie,CHEN Xu, et al. The impact of obstructive sleep apnea hypopnea syndrome on cognitive processing in children[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2023, 53(10): 789-794.
Abstract：Objective: To investigate the effects of obstructive sleep apnea hypopnea syndrome (OSAHS) on cognitive processing in children by using Das-Naglieri Cognitive assessment system (DN:CAS). Methods: Forty children aged 8-13, who were diagnosed with OSAHS by polysomnography (PSG), were selected as the OSAHS group, and 30 healthy children as the control group. The general characteristics, sleep monitoring parameters,and DN:CAS cognitive assessment results of both groups were statistically analyzed. Results: Compared with the healthy controls, the OSAHS group had a higher proportion of stage-1 sleep and obstructive apnea hypopnea index (OAHI), but lower proportion of stage-3 sleep, REM sleep, and the minimum blood oxygen saturation (LSaO2), which showed statistically significant differences (P<0.05). The cognitive assessment using DN:CAS revealed that the OSAHS group had significantly lower scores in Full Scale, Planning, Matching Numbers, Planned Connections, Attention, Receptive Attention, Number Detection, and Expressive Attention, compared with the control group with statistically significant differences (P<0.05). The scores of Full Scale and Attention of DN:CAS in the OSAHS group were positively correlated with LSaO2 (r=0.331, 0.365, P<0.05). Conclusion:Children with OSAHS exhibit deficits in cognitive processing, primarily in the areas of planning and attention.Nocturnal hypoxia is associated with attention deficits in children with OSAHS. The DN:CAS assessment system has demonstrated potential value in evaluating the cognitive processing of children with OSAHS.
