The correlation between reduced serum uric acid levels and cognitive impairment in patients with depressive disorder
HUANG Ziye1, ZHENG Ke2, CHEN Ce1, TU Wenzhen1
1.Department of Psychiatry, the Seventh People’s Hospital of Wenzhou, Wenzhou 325006, China; 2.Department of Psychiatry, Kangning Hospital Affiliated to Wenzhou Medical University, Wenzhou 325000, China
HUANG Ziye,ZHENG Ke,CHEN Ce, et al. The correlation between reduced serum uric acid levels and cognitive impairment in patients with depressive disorder[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2023, 53(9): 740-743,748.
Abstract：Objective: To explore the changes in serum uric acid (SUA) levels and their relationship with cognitive impairment in patients with depression. Methods: A total of 110 depressive patients and healthy adults were recruited from January 2022 to December 2022 at the Seventh People’s Hospital of Wenzhou, who were divided as depression group (55) and a healthy control group (55). Repeatable Battery for the Assessment of Neuropsychological (RBANS) was used to assess the cognitive functions of the two groups, including immediate memory, visuospatial, language function, attention function, delayed memory, and SUA levels were also estimated. Results: After controlling covariates, the SUA levels, immediate memory, attention function, language function, delayed memory, and total RBANS score of the depression group were lower than those of the control group, with statistically significant difference (P<0.05). After Bonferroni correction, there were still significant differences between the two groups in immediate memory, language function, and attention (P<0.05). There was a positive correlation between SUA levels and immediate memory (r=0.315, P=0.019), attention function (r=0.401, P=0.002), language function (r=0.353, P=0.008), delayed memory (r=0.412, P=0.002), and RBANS total score (r=0.397, P=0.003) in the depression group. Multiple linear regression suggested a positive correlation between SUA levels and language (B=0.127, P=0.044) and attention function (B=0.166, P=0.036) in patients with depression.Conclusion: Our results suggest that reduced SUA levels might be implicated in the pathophysiology of cognitive impairment in depressive disorder.
