Pathogenic bacteria distribution and antimicrobial susceptibility in children with bloodstream infections
PAN Ya’nan, ZHOU Jinhui, ZHANG Manman, MAO Huining, LI Siyu, HAN Hao, YUAN Xiang, TU Huixi, LIN Li.
Department of Pediatric Respiratory Diseases, the Second Affiliated Hospital & Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou 325027, China
PAN Ya’nan,ZHOU Jinhui,ZHANG Manman, et al. Pathogenic bacteria distribution and antimicrobial susceptibility in children with bloodstream infections[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2023, 53(5): 392-398.
Abstract：Objective: To study the distribution of pathogenic bacteria and antimicrobial susceptibility with bloodstream infections in children. Methods: Clinical data, distribution of pathogenic bacteria and antimicrobial susceptibility test results of children with bloodstream infections admitted to the Second Affiliated Hospital & Yuying Children’s Hospital of Wenzhou Medical University from January 2016 to December 2021 were analyzed retrospectively. Results: A total of 538 pathogenic strains were detected in 528 cases, Gram-positive bacteria (55.4%), Gram-negative bacteria (42.2%) and fungi (2.4%) were detected, and the top 3 pathogens were Escherichia coli, coagulase-negative Staphylococcus, and Streptococcus pneumoniae. The main pathogens of bloodstream infections in children aged < 1 years were Escherichia coli (30.6%), and Streptococcus pneumoniae (28.7%) was the main pathogen in ≥1 year old. Central line-associated bloodstream infection was reported in 36 cases, with Staphylococcus epidermidis (36.1%) as the main pathogen. The proportion of producing extended spectrum β-lactamases (ESBLs) of Escherichia coli and Klebsiella pneumoniae was 50.8% and 40.9%,respectively. The sensitivity of ESBLs-producing Escherichia coli to β-lactamase enzyme inhibitors was less than 70.0%. The proportion of methicillin-resistant Staphylococcus epidermidis (MRSE) and Staphylococcus aureus (MRSA) was 93.5% and 54.5%, respectively, and no strains resistant to vancomycin and linezolid were found. One strain of Enterococcus faecalis intermediate to linezolid and one strain of Streptococcus pneumoniae intermediate to vancomycin were detected. Conclusion: The distribution of BSI pathogenic bacteria varies among children at different ages. The proportion of ESBLs-producing Escherichia coli, Klebsiella pneumoniae,MRSE, MRSA is high. The distribution of pathogenic bacteria and antimicrobial susceptibility of bloodstream infections in children should be continuously monitored, and antimicrobial drugs should be used rationally.
