Abstract：Objective: To explore the related risk factors for sleep disorder in maintenance hemodialysis (MHD) patients so as to provide theoretical basis for clinical prevention and treatment. Methods: A total of 200 MHD patients who visited the hemodialysis center of Wenzhou Central Hospital from January 2022 to August 2022 were selected. MHD patients were divided into non-sleep disorder group and sleep disorder group according to the Pittsburgh sleep quality index (PSQI) scale. With general data of the two groups obtained, their blood samples were collected before hemodialysis in the month of investigation. The two groups were compared in the differences of each clinical index and their correlation with the occurrence of sleep disorder. Results: The incidence of sleep disorder in 200 MHD patients was 66.5% (133/200). There were significant differences between the two groups (P<0.05) in age, proportion of constipation, proportion of diabetes, proportion of skin pruritus,hemoglobin, blood phosphorus, iPTH, hs-CRP, BMI, Kt/V and 25(OH)D3 levels. Further multivariate Logistic regression analysis showed that age, hs-CRP, hemoglobin, Kt/V, 25(OH)D3, combined constipation and combined skin pruritus were associated with sleep disorder in MHD patients (P<0.05). Conclusion: Older age, high level of hs-CRP, low level of hemoglobin, low level of Kt/V, low level of 25(OH)D3, constipation and skin pruritus were independent risk factors for sleep disorder in MHD patients.
