Significance of peripheral blood platelet/lymphocyte ratio and its changes in clinical features and prognosis of patients with early cervical cancer
ZHANG Fan1, DU Junqiang1, WANG Chaoqun2, HU Yan3
1.Departmentof Gynecology, Affiliated Dongyang Hospital of Wenzhou Medical University, Jinhua 322100, China; 2.Department of Pathology, Affiliated Dongyang Hospital of Wenzhou Medical University, Jinhua 322100, China; 3.Department of Gynecology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China
ZHANG Fan,DU Junqiang,WANG Chaoqun, et al. Significance of peripheral blood platelet/lymphocyte ratio and its changes in clinical features and prognosis of patients with early cervical cancer[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2023, 53(3): 227-232.
Abstract：Objective: To explore the effects of platelet/lymphocyte ratio (PLR) level and its change preand post-operation on patients with early cervical cancer, and to analyze the relationship between PLR and clinical features and prognosis. Methods: Clinical, pathological and prognostic data of 203 patients with stage I-IIA cervical cancer admitted to Affiliated Dongyang Hospital of Wenzhou Medical University from January 2012 to December 2017 were retrospectively collected. PLR was calculated by dividing the value of peripheral blood platelets by the absolute value of lymphocytes. The patients were divided as PLR high-level group and low-level group, before and after operation respectivel, based on the median value of PLR. The differences of clinicopathological characteristics and prognosis between groups were compared. Results: The preoperative PLR level was negatively correlated with age (P=0.010) and menopausal status (P<0.001), while postoperative PLR level was positively correlated with lymph node metastasis (P=0.012). The increase of PLR level after operation was positively correlated with the menopause status of patients (P=0.011). Survival analysis showed that there was no significant difference in the overall survival rate and progression free survival rate between groups with high and low levels of PLR before and after surgery, and between groups with increased and decreased levels of PLR after surgery (P>0.05), suggesting that it was not related to the prognosis of cervical cancer. Cox regression analysis showed that clinical staging was an independent influence factor for 5-year DFS in patients with early cervical cancer. Conclusion: PLR level and changes pre- and post- operation are closely related to some clinicopathological features in early cervical cancer patients, but not associated with the prognosis of patients.
