The resistance spectrum of escherichia coli in bloodstream infection
1.Respiratory & Critical Care Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015; 2.Laboratory Diagnostic Centre, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015
YAO Dan1,YU Fangyou2,HUANG Xiaoying1, et al. The resistance spectrum of escherichia coli in bloodstream infection[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2014, 44(12): 917-919.
Abstract：Objective: To investigate the drug resistance of escherichia coli isolated from patients with bloodstream infection to commonly used antibiotics, and to provide reference for clinical anti-infective drug therapy. Methods: The France Bio-Merieux company VITEK-60 compact automatic bactecial identification instrument was employed to identify the bactecia. According to the (NCCLS) 2005, the double disk confirmatory test were adopted to detect ESBLs, and K-B disk diffusion assay was used to determine antibiotic resistance of escherichia coli. Results: Totally 175 strains of escherichia coli were isolated from the samples, among them, ESBLs-producing strains accounted for 52.6% (92/175). The drug resistence of ESBL-producing escherichia coli to ampicillin, cefazolin, ceftriaxone, ceftazidime were 98.9%, 97.8%, 94.6%, 83.7% respectively, which were significantly higher than that of non-ESBL-producing escherichia coli. The drug resistence of ESBL-producing escherichia coli to trimesulf, ciprofloxacin, gentamycin, tobramycin, levofloxacin were 76.1%, 57.6%, 57.6%, 58.7%, 69.6% respectively. The drug resistence rate to piperacillin tazobactam and macrodantin were almost similar in ESBL-producing escherichia coli and non-ESBL-producing escherichia coli. And the whole escherichia coli were sensitive to tienam and vancomycin. Conclusion: Escherichia coli as the major gram-negative bacterium led to bloodstream infection, its resistance phenomenon to common antibiotics was serious. It is necessary to pay more attention to the the drug resistance to provide reference for clinical anti-infective drug therapy.
