The expression of long noncoding RNA lnc-CCDC33-1:1 in papillary thyroid carcinoma and its clinical significance
LI Pengping1, LAN Xiabin2, HUANG Yuqing1
1.Department of Thyroid and Breast Surgery,Xiaoshan Hospital Affiliated to Wenzhou Medical University, the First People’s Hospital of Xiaoshan District, Hangzhou 311201, China; 2.Department of Head and Neck Surgery, Cancer Hospital Affiliated to the University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou 310005, China
LI Pengping,LAN Xiabin,HUANG Yuqing. The expression of long noncoding RNA lnc-CCDC33-1:1 in papillary thyroid carcinoma and its clinical significance[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2023, 53(2): 127-131.
Abstract：Objective: To evaluate the expression of lnc-CCDC33-1:1 in papillary thyroid carcinoma (PTC) and its clinical significance. Methods: A total of 120 patients with PTC admitted to the First People’s Hospital of Xiaoshan District, Hangzhou from November 2021 to March 2022 were selected. The expression levels of lnc-CCDC33-1:1 were detected in 120 PTC and 30 adjacent noncancerous thyroid tissues by quantitative realtime polymerase chain reaction. The relationships between the expression of lnc-CCDC33-1:1 in PTC and the clinicopathologic factors were analyzed both in our cohort and TCGA cohort. Receiver operating characteristic (ROC) curves were generated to assess the diagnostic value of lnc-CCDC33-1:1 as a biomarker for PTC. Results: The expression of lnc-CCDC33-1:1 was significantly upregulated in PTC tissues compared with adjacent noncancerous tissues (P<0.001). The ROC curves revealed that lnc-CCDC33-1:1 had a potential diagnostic value in predicting malignancy. The area under curves was 0.803 (95%CI=0.736-0.869, P<0.001). The local cohort showed that the expression of lnc-CCDC33-1:1 was correlated with PTC tumor size (P=0.048), extraglandular invasion (P=0.019), T stage (P=0.011), and lymph node metastasis (P=0.009). TCGA group data showed that the expression level of lnc-CCDC33-1:1 was correlated with PTC extraglandular invasion (P=0.036), and lymph node metastasis (P<0.001). Conclusion: The abnormally upregulated expression of lnc-CCDC33-1:1 in PTC is correlated with high-risk characteristics of PTC. Therefore, it may serve as a potential diagnostic biomarker or lnctreatment
target for PTC.
