Correlation between cognitive changes and brain white matter network in children with obstructive sleep apnea
CHEN Fangfang1, FU Yuchuan1, LU Yi1, YU Chenyi2, WANG Yu3, CHEN Tao4, YAN Zhihan1, LYU Su1, 5.
1.Department of Radiology, the Second Affiliated Hospital & Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou 325027, China; 2.Department of Pediatric Sleep Medcine, the Second Affiliated Hospital &Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou 325027, China; 3.Department of Radiology,Ningbo First Hospital, Ningbo 315010, China; 4.Department of Radiology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China; 5.Department of Radiology, West China Hospital of Sichuan University, Chengdu 610044, China
CHEN Fangfang,FU Yuchuan,LU Yi, et al. Correlation between cognitive changes and brain white matter network in children with obstructive sleep apnea[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2023, 53(2): 87-92.
Abstract：Objective: To investigate the cognitive function and brain white matter network alterations in children with obstructive sleep apnea (OSA) and the correlation between them. Methods: From February 2018 to November 2020, a total of 29 age - and sex-matched OSA children and 21 healthy controls aged 7-13 years were collected at the Second Affiliated Hospital & Yuying Children’s Hospital of Wenzhou Medical University for high-resolution 3D T1WI and DTI scanning. Global attributes (assortativity) and nodal attributes (clustering coefficient, degree centrality, local efficiency) of the white matter network and DN: CAS scale scores were calculated for each participant, compared between groups, and correlations between white matter network attributes and cognitive scores were analyzed using hierarchical linear regression. Results: Without FDR correction, the degree centrality of the right supplementary motor area, the right heschl gyrus and the clustering coefficients of the left postcentral gyrus and the right heschl gyrus, as well as the local efficiency of the left anterior cingulate and paracingulate gyri and the right heschl gyrus increased in the OSA group compared with healthy controls; the degree centrality of the left orbital part of middle frontal gyrus, the left lingual gyrus and the left middle temporal gyrus, the clustering coefficients of the right middle temporal gyrus and the local efficiency of the right middle temporal gyrus decreased in the OSA group compared with healthy controls. Degree centrality in the left middle temporal gyrus was positively correlated with word series in DN: CAS (β=0.421, P=0.015),clustering coefficient in the right middle temporal gyrus (β=0.507, P=0.023) and local efficiency (β=0.504,P=0.010) with simultaneous processing scale scores. Conclusion: The white matter network in children with OSA has a tendency to change, in which the nodal properties of the middle temporal gyrus are associated with cognition, suggesting that abnormalities in the brain white matter network, especially alterations in the structure of the middle temporal gyrus, may be the neural basis of cognitive impairment in children with OSA.
