The functions and drug development of ecto-nucleotide pyrophosphatase/phosphodiesterase-1
LIU Yitang1,DING Zihan1, CHENG Wenqing1, CAI Zheyang1, SHEN Linjie1, GUO Wei1, 2.
1.School of Ophthalmology &Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou 325035, China; 2.The Molecular Neuropharmacology Laboratory and the Eye-Brain Research Center, The State Key Laboratory of Ophthalmology, Optometry and Vision Science, Wenzhou Medical University, Wenzhou 325035, China
LIU Yitang,DING Zihan,CHENG Wenqing, et al. The functions and drug development of ecto-nucleotide pyrophosphatase/phosphodiesterase-1[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2022, 52(12): 1020-1025.
Abstract：The extracellular adenosine metabolism system, which is involved in numerous and varied physiological and pathological processes, has drawn wide interest as targets for new drug development.However, the research progress of drug development targeting ecto-nucleotide pyrophosphatase/phosphodiesterase-1 (ENPP1) is rare. Recently, the roles of ENPP1 have received progressive attention after the breakthrough finding as the dominant 2’3’-cyclic GMP-AMP dinucleotides-hydrolase. Here, having briefly introduced the structure of ENPP1, we focus on its physiological and pathological functions in biomineralization and tumor, as well as the research and development of enzyme replacement therapy and small molecule drugs targeting ENPP1.
