Effective dose of esketamine for inhibiting body movement in hysteroscopic patients
LI Shuangfeng1,CHEN Zhongren2, HUANG Tingwan1, HAN Tiechao1, LI Na2
1.Department of Anesthesiology, Haikou Maternity and Child Health Hospital, Haikou Women and Children’s Hospital, Haikou 570102, China;2.Department of Anesthesiology, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou 570311, China
LI Shuangfeng,CHEN Zhongren,HUANG Tingwan, et al. Effective dose of esketamine for inhibiting body movement in hysteroscopic patients[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2022, 52(11): 919-922.
Abstract：Objective: To investigate the effective dose of esketamine for inhibiting body movement in hysteroscopic patients when combined with 3 μg·mL-1 propofol of plasma target control infusion. Methods: A total of 26 patients who received hysteroscopy with general anesthesia from Haikou Maternity and Child Health Hospital during December 2021 to February 2022 were selected. 3 μg·mL-1 propofol of plasma target control infusion was given when esketamine was injected, with the initial dose of 0.5 mg·kg-1. Dose of esketamine was determined by up-and-down sequential method, with the common ratio of esketamine dose in adjacent patients being 0.9. Probit analysis was used to calculate the median effective dose (ED50) and 95% effective dose (ED95) and the corresponding 95% confidence interval (CI). The circulation, respiration, body movement, operation time,awakening time and VAS score 10 minutes after awakening in surgery were observed. Respiratory depression (SpO2<90%), hypotension, nausea and vomiting, recovery agitation, dizziness, and nightmare were recorded.Results: The ED50 of esketamine combined with 3 μg·mL-1 propofol for inhibiting body movement in patients with hysteroscopy was 0.391 mg·kg-1 (95%CI=0.340-0.431 mg·kg-1), ED95 was 0.476 mg·kg-1 (95%CI=0.434-0.778 mg·kg-1). The operation time was (24.84±8.45) min, the time to awaken was (7.16±3.23) min, the median VAS score 10 minutes after awakening was 1(1, 2) scores. No patients had respiratory depression, hypotension or nightmare. Three patients had dizziness, and two had vomiting and one patient had agitation. Conclusion: The ED50 and ED95 of esketamine for inhibiting body movement in patients with hysteroscopy was 0.391 mg·kg-1 and 0.476 mg·kg-1 respectively when combined with propofol 3 μg·mL-1.
