Risk factors of lymphovascular invasion in T1 breast cancer
MIAO Haiwei1, LIU Xinmiao2, ZHOU Jiejie1,ZHAO Youfan1, LIU Huiru1, WANG Meihao1.
1.Department of Radiology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325015, China; 2.School of Laboratory, Medicine and Life Sciences,
Wenzhou Medical University, Wenzhou 325035, China
MIAO Haiwei,LIU Xinmiao,ZHOU Jiejie, et al. Risk factors of lymphovascular invasion in T1 breast cancer[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2022, 52(11): 876-881.
Abstract：Objective: To investigate the risk factors for lymphovascular invasion (LVI) in patients with breast invasive ductal carcinoma (IDC) stage T1. Methods: The clinic-pathological data and preoperative magnetic resonance images of T1 IDC patients were retrospectively collected from January 2017 to June 2022 in the First Affiliated Hospital of Wenzhou Medical University. According to the LVI results, they were divided into two groups. Tumor-related breast edema was classified into 4 grades according to the Breast Edema Score (BES) on T2-weighted images (T2WI). To simplify it, BES2 was classified as slight edema, and BES3 and BES4 were combined as moderate to severe edema. Univariate analysis and binary logistic regression model were used for statistical analysis to determine whether the characteristics of IDC were associated with LVI. Results: A total of 307 patients were included in this study, of whom 262 were LVI negative and 45 were LVI positive. Compared with low histological grade and negative lymph node metastasis, high histological grade (OR=2.59, 95%CI=1.19-5.61, P=0.016) and positive lymph node metastasis (OR=4.74, 95%CI=2.39-9.43, P<0.001) was more likely to be LVI positive. Compared with no edema, slight edema (OR=3.80, 95%CI=1.78-8.14, P=0.001) and moderate to severe edema (OR=5.54, 95%CI=2.25-13.60, P<0.001) had an increased probability of LVI positive, but there was no significant difference between groups (P>0.05). Conclusion: Breast edema, lymph node status and histological grade are independent risk factors for LVI in T1 breast IDC patients.
