ZHANG Jinyi,HUANG Luoqi,WU Zhen, et al. The infection status of streptococcus agalactiae and antimicrobial resistance in 43034 pregnant women in the third trimester of pregnancy[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2022, 52(10): 833-836.
Abstract：Objective: To analyze the infection status and antibiotic resistant of Group B streptococcus (GBS) in the third trimester of pregnancy women in Wenzhou, and to compare the infection status of pregnant women between different age groups. Methods: Data were collected from 43 034 pregnant women in third trimester of pregnancy (36-42 gestational week) treated in the Obstetrics Department of the Second Affiliated Hospital of Wenzhou Medical University from January 2016 to December 2020. The statistical analysis was conducted on GBS culture and antibiotic sensitivity test of their urogenital tract, accompanied with the comparison in the detection of GBS in the third trimester of pregnancy of different ages. Results: Of 43 034 pregnant women,2 928 cases of GBS lactis were detected from the urogenital tract samples with a detection rate of 6.80%. The detection rate displayed an upward trend from 2016 to 2019, as was the highest in 2019, showing statistical difference (P<0.05); the detection rate had a slight decrease in 2020, but exhibited no significant difference. The detection rate was the highest in the pregnant women over 40 years old (7.92%), with statistical significance (P<0.05). In the drug sensitivity test of pregnant women with GBS infection, the sensitivity rate to vancomycin was found to be 100.00%, and the highest antibiotic resistance was erythromycin (74.11%), followed by clindamycin (72.81%), levofloxacin (37.06%), with significant difference among the three drugs (P<0.05).Conclusion: The detection rate of GBS in the third trimester of pregnancy women in Wenzhou was relatively high, reaching about 6.80%, highest in the pregnant women over 40 years. For pregnant women with GBS infection, penicillin is still the preferred prophylactic drug during labor. For women with penicillin allergy, antibiotics should be reasonably used according to the results of drug sensitivity test.
