Retrospective analysis of clinical features in adults with anti-sulfatide positive Guillain-Barré syndrome
MIN Jingjing1, CHEN Qi2,WANG Xiaotong3
1.Department of Neurology, Huzhou First People’s Hospital,Huzhou 313000, China; 2.Department of Nephrology, Huzhou First People’s Hospital, Huzhou 313000, China;3.Department of Rehabilitation, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027,China
MIN Jingjing,CHEN Qi,WANG Xiaotong. Retrospective analysis of clinical features in adults with anti-sulfatide positive Guillain-Barré syndrome[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2022, 52(9): 752-756.
Abstract：Objective: To investigate the clinical characteristics, treatment and prognosis of Guillain-Barre syndrome (GBS) in adults with anti-sulfatide antibody positive. Methods: Data of 3 patients with anti-sulfatide antibody positive in Huzhou First People’s Hospital from February 2020 to December 2021 were collected for clinical analysis and follow-up, and relevant literatures were reviewed. Results: Of the 3 patients, 2 males aged 84 and 66 respectively, and 1 female aged 26. One of them had a history of secondary severe infection after esophageal malignant tumor surgery more than 10 days before the onset of the disease, and another had a history of vaccination 1 week before the onset of the disease. In terms of clinical manifestations, 1 patient presented progressive numbness and weakness of lower limbs, 2 patients presented acute progressive numbness and weakness of limbs, and 1 patient complicated with dyspnea and was intubated.The electrophysiological results showed that the conduction velocity and amplitude of motor and sensory nerve decreased in all the three cases, obvious in the lower limbs, with axonal of sensory nerve mainly injured. In all 3 patients, lumbar puncture indicated protein cell separation, positive anti-sulfatide antibody in the cerebrospinal fluid and no obvious abnormality found on the
head MRI. As to the treatment, 2 patients were significantly improved by IVIG therapy. As one patient’s family members refused immunotherapy, the patient successfully extubatedafter active anti-infection, but there was still obvious disorder in limb function. Conclusion: Adults with Guillain-Barré syndrome with positive anti-sulfatide antibody can be involved in sensorimotor of extremities, with more obvious sensory disorders. Electrophysiology shows that sensory axonal is mainly affected. Immunotherapy is effective, and the overall prognosis is good.
