Diagnostic value of 1-3-β-D glucan, LDH, CD4+ T lymphocytes and CRP combined detection for AIDS complicated with pneumocystis pneumonia: a datum mining analysis
WU Lianpeng1, 2, PAN Sihang3, XU Ke1, 2
1.Department of Clinical Laboratory Medicine, the Dingli Clinical Institute of Wenzhou Medical University, Wenzhou 325000, China; 2.Key Laboratory for Diagnosis and Treatment of New and Recurrent Infectious Diseases of Wenzhou, Wenzhou 325000, China; 3.School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou 325035, China
WU Lianpeng,PAN Sihang,XU Ke. Diagnostic value of 1-3-β-D glucan, LDH, CD4+ T lymphocytes and CRP combined detection for AIDS complicated with pneumocystis pneumonia: a datum mining analysis[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2022, 52(9): 736-740,746.
Abstract：Objective: To explore the diagnostic value of combined detection of 1-3-β-Dglucan, lactate dehydrogenase, CD4+ T lymphocytes and C-reactive protein in AIDS complicated with pneumocystis pneumonia.Methods: A total of 315 AIDS patients treated in Wenzhou Sixth People’s Hospital from April 2016 to February 2022 were selected as subjects, of whom170 patients with pneumocystis pneumonia were assigned as the study group (AIDS/PCP group) and 145 patients without pulmonary infection as the control group (AIDS group). The levels of 1-3-β-D glucan, LDH, CD4+ T lymphocytes and CRP in the two groups were detected, and the multilayer
perceptron (MLP) neural network model, Chi-square automatic interactive detection (CHAID) decision tree model and Logistic regression model were constructed. The diagnostic efficacy of 1-3-β-D glucan, LDH, CD4+ T lymphocytes and CRP in the diagnosis of AIDS complicated with PCP was evaluated by receiver operating characteristic (ROC) curve. Results: The levels of 1-3-β-D glucan, LDH and CRP in AIDS/PCP group were significantly higher than those in AIDS group, while the count of CD4+ T lymphocytes was significantly lower than that of AIDS group (P<0.001). The specificity, sensitivity and accuracy of the constructed MLP neural network model of 1-3-β-D glucan, LDH, CD4+ T lymphocytes and CRP in the diagnosis of AIDS complicated with PCP were 88.97%, 86.47% and 87.62%, respectively, with the area under the curve (AUC) being 0.942. The specificity, sensitivity and accuracy of the decision tree model were 70.34%, 84.12%, 77.78%, respectively, with the area under the curve being 0.871. The specificity, sensitivity and accuracy of Logistic regression model were 89.66%,84.71%, 86.98%, respectively, with the area under the curve being 0.939. Conclusion: MLP neural network model combined with 1-3-β-D glucan, LDH, CD4+ T lymphocytes and CRP detection has good auxiliary value in the diagnostic of AIDS complicated with PCP.
