The value of automated cardiac motion quantification technique in evaluating subclinical anthracyclineinduced cardiotoxicity in children with acute lymphoblastic leukemia
CHEN Kai1, WU Daozhu1, YE Wanding2, WANG Liang1, ZHOU Lin1
1.Department of Ultrasonography, the Second Affiliated Hospital & Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou 325027, China; 2.Department of General Pediatrics, the Second Affiliated Hospital & Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou 325027, China
CHEN Kai,WU Daozhu,YE Wanding, et al. The value of automated cardiac motion quantification technique in evaluating subclinical anthracyclineinduced cardiotoxicity in children with acute lymphoblastic leukemia[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2022, 52(9): 718-723.
Abstract：Objective: To investigate the value of automated cardiac motion quantification (aCMQ) in evaluating subclinical anthracycline-induced cardiotoxicity in children with acute lymphoblastic leukemia (ALL). Methods: Altogether 30 children with ALL who were treated with DVLD induced chemotherapy in the Second Affiliated Hospital & Yuying Children’s Hospital of Wenzhou Medical University from November 2021 to January 2022 were selected as leukemia group. Echocardiography was performed before chemotherapy and 3 months later.Twenty-six healthy subjects were selected as the control group. Transthoracic echocardiography was performed to obtain left ventricular ejection fraction (LVEF), left ventricular short axis shortening (LVFS), E/A, E/e’, and e’/a’. The longitudinal strains of 2 chamber (AP2LS), 3 chamber (AP3LS), 4 chamber (AP4LS) and global longitudinal strain (LVGLS) were obtained by aCMQ technique. The annular strains of left ventricular short-axis basal segment
(SAXBCS), left ventricular short-axis intermediate segment (SAXMCS), left ventricular short-axis apical segment (SAXACS) and global circular strain (LVGCS) were compared and analyzed. Results: There were no significant differences in age between the leukemia group and the control group (P>0.05). There were no significant differences in LVEF, LVFS, E/A, E/e’ and e’/a’ between the control group, the pre-chemotherapy group and the post-chemotherapy group (P>0.05). The values of AP4LS, AP3LS, AP2LS, GLS, SAXBCS, SAXMCS, SAXACS and GCS in the pre-chemotherapy group were compared with those in the control group, with no significant difference (P>0.05). There was no significant difference in SAXBCS and SAXMCS between the group after chemotherapy and the control group before and after chemotherapy (P>0.05). The absolute values of AP4LS,AP3LS, AP2LS, GLS, SAXACS and GCS in the post-chemotherapy group were lower than those in the control group and the pre-chemotherapy group, with statistical difference (P<0.05). Conclusion: aCMQ can be used as a relatively accurate method for evaluating subclinical anthracycline-induced cardiotoxicity in children with ALL.
