Lymphoepithelioma-like carcinoma in the liver: clinicopathological features and MRI findings of 7 cases
GAO Yang1, SUN Hongming2, CHEN Chunmiao1, JI Jiansong1
1.Department of Radiology, Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, the Fifth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, China; 2.Department of Pathology, the Fifth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, China
GAO Yang,SUN Hongming,CHEN Chunmiao, et al. Lymphoepithelioma-like carcinoma in the liver: clinicopathological features and MRI findings of 7 cases[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2022, 52(7): 575-576，581.
Abstract：Objective: To investigate the clinicopathological features and MRI findings of 7 cases with lymphoepithelioma-like carcinoma of liver. Methods: A retrospective analysis was carried out focusing on the clinicopathological features and MRI findings of 7 cases with lymphoepithelioma-like carcinoma of liver, who were confirmed by surgery and pathological examination in our hospital from December 2009 to December 2021. Results: Of 7 patients, there were 2 males and 5 females, with a median age of 54 years old. There were 4 cases of HBV (+), and all cases showed HCV (-), among which 1 case was accompanied by liver cirrhosis and elevated serum AFP level (389.7 ng/mL). Further pathological diagnosis reported 1 case of lymphoepithelioma like
hepatocellular carcinoma, and 6 cases of lymphoepithelioma like cholangiocarcinoma. Microscopically, there was infiltration of a large number of lymphocytes in the tumor tissue. EBER in situ hybridization was positive in 6 cases. MRI showed that the tumors with nodular appearance in 5 cases, regular morphology in 6 cases and clear boundary in 6 cases. T1WI showed low signal, while T2WI showed high signal. Meanwhile, 2 cases showed slightly high signal and 5 cases displayed significantly high signal on DWI. Furthermore, there were various enhancement patterns, including 3 cases of type I (wash-in and wash-out enhancement); 2 cases of type II (continuous annular enhancement); and 2 cases of type III (marginal filling enhancement). Capsular-like enhancement was visible in type I and II lesions. There was no abnormal enhancement around the tumor, no bile duct dilatation or hepatic capsule retraction in all lesions. Conclusion: Clinically rare, lymphoepithelioma-like carcinoma of liver has relatively good prognosis with certain pathological characteristics. MRI manifestations are mainly rounded nodules with various enhancement, mostly capsular-like enhancement.
