Comparison of preoperative immune-inflammation index and carcinoembryonic antigen in different pathological types of ground-glass opacity
WAN Hui1, GAO Meiling1, LIN Jie1, SHI Shengqiao1, QUAN Duoduo2, KONG Chengying3, DAI Yuanrong1
1.Department of Respiratory Medicine, the Second Affiliated Hospital & Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou 325027, China; 2.Department of Pathology, the Second Affiliated Hospital & Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou 325027, China; 3.Department of Respiratory Medicine, the Fourth Affiliated Hospital of Zhejiang University School of Medicine, Jinhua 322000, China
WAN Hui,GAO Meiling,LIN Jie, et al. Comparison of preoperative immune-inflammation index and carcinoembryonic antigen in different pathological types of ground-glass opacity[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2022, 52(7): 557-561.
Abstract：Objective: To compare the preoperative neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), lymphocyte to monocyte ratio (LMR) and serum carcinoembryonic antigen (CEA) in different pathological types of ground-glass opacity (GGO) in order to explore whether there were differences
and their significance. Methods: The NLR, PLR and LMR of 494 GGO patients who underwent surgical treatment were collected, including 176 cases of infiltrating adenocarcinomas, 150 cases of minimally invasive adenocarcinoma, 117 cases of precursor glandular lesions and 51 cases of benign lesions. Serum CEA was collected from only 150 infiltrating adenocarcinomas, 127 minimally invasive adenocarcinomas, 95 precursor glandular lesions, and 45 benign lesions. The NLR, PLR, LMR, and serum CEA of each pathological group were compared. Results: The NLR of the precursor glandular lesion group (2.32±1.59) was higher than that of the benign lesion group (1.82±0.64) (P<0.05). The PLR in lung adenocarcinoma group (141.19±53.14) and in precursor glandular lesion group (145.94±51.92) was both higher than that of the benign lesion group (124.90± 37.04) (all P<0.05). The CEA of lung adenocarcinoma group [1.83 (1.18, 2.73) ng/mL] was higher than that of the control group (precursor glandular lesions+benign lesions) [1.49 (1.03, 2.08) ng/mL] (P<0.01). The CEA in infiltrating adenocarcinoma group [2.14 (1.29, 2.92) ng/mL] was higher than that of minimally invasive adenocarcinoma group [1.67 (1.09, 2.43) ng/mL], precursor glandular lesion group [1.46 (1.03, 2.06) ng/mL], and benign lesion group [1.53 (1.00, 2.10) ng/mL] (P<0.05). Conclusion: Systemic immune inflammatory index begins to change in early-stage lung adenocarcinoma, even in the stage of precursor glandular lesions, and serum CEA begins to change in early-stage lung adenocarcinoma. Dynamic observation of the changes in the above indicators is conducive to the early detection and early intervention of malignant lesions.
