The application value of serum β-Amyloid level in the occurrence and prognosis of knee osteoarthritis
XU Yu1, XIE Qipeng2, CHEN Shaomin3, YE Hantao1, LI Feida1, SHUI Xiaolong1
1.Department of Orthopaedics, the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University,Wenzhou 325027, China; 2.Department of Laboratory Medicine, the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou 325027, China; 3.Department of Rehabilitation Medicine, the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University,Wenzhou 325027, China
XU Yu,XIE Qipeng,CHEN Shaomin, et al. The application value of serum β-Amyloid level in the occurrence and prognosis of knee osteoarthritis[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2022, 52(4): 272-276.
Abstract：Objective: To investigate the correlation between the level of β-Amyloid in the serum of patients with knee osteoarthritis (KOA) and the severity, occurrence and prognosis of knee osteoarthritis.Methods: Fifty-six KOA patients who underwent arthroscopic or total knee arthroplasty were assignied as the experimental group and 25 routine patients as the control group. Patients in the experimental group were graded according to X-ray Kellgren-Lawrence (K-L) grading method; and serum samples were collected before and after operation, and serum β-Amyloid level was measured by double antibody sandwich ELISA. The correlation between serum β-Amyloid level and prognosis of KOA were evaluated by ROC curve. Spearman rank correlation was used to analyze the relationship between serum serum β-Amyloid level and the severity of KOA. Pearson correlation was used to analyze the relationship between the changes in serum β-Amyloid and the length of hospital stay. Results: The level of serum β-Amyloid in KOA patients was higher than that in control group (P<0.001).Logistic regression showed that β-Amyloid was a risk factor for KOA, and the OR value was 15.122. ROC curve analysis showed the β-Amyloid cut off was 0.770, the area under β-Amyloid curve 0.752, 95%CI 0.636-0.867,
sensitivity 85.5% and specificity 60.0%. K-L2 patients had lower level of serum β-Amyloid than K-L3/4 patients (P=0.041), and Spearman rank correlation analysis showed that β-Amyloid expression was significantly positively correlated with KOA severity (r=0.332, P=0.013). The level of β-Amyloid in KOA patients before operation was higher than after operation (P=0.002), and Pearson correlation analysis showed that the changes of serum β-Amyloid had significantly negative correlation with the length of hospital stay in KOA patients (r=-0.949,P<0.001). Conclusion: β-Amyloid is a risk factor for KOA. The serum β-Amyloid level may become a potential biomarker for evaluating the occurrence and prognosis of KOA.
