Effect of small airway dysfunction on static lung function index in the elderly and its significance in the identification of labor ability
PAN Jing1, ZHENG Yongke1, LIN Wen2, DAI Xinjian3
1.Geriatric Medicine, Wenzhou Central Hospital, the Second Affiliated Hospital of Shanghai University, Wenzhou 325000, China; 2.Pulmonary Function Chamber, Wenzhou Central Hospital,the Second Affiliated Hospital of Shanghai University, Wenzhou 325000, China; 3.Respiratory and Critical Care Medicine Department, Wenzhou Central Hospital, the Second Affiliated Hospital of Shanghai University, Wenzhou 325000, China
PAN Jing,ZHENG Yongke,LIN Wen, et al. Effect of small airway dysfunction on static lung function index in the elderly and its significance in the identification of labor ability[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2022, 52(3): 222-225,229.
Abstract：Objective: To study the influence of small airway dysfunction on static lung function index in the elderly. Methods: According to the inclusion and elimination criteria, 60 cases of normal lung function group (control group) and 94 cases of simple small airway dysfunction group (observation group) were selected. The various lung function indicators were compared between the two groups. Persion correlation analysis of the small airway and static lung function indexes was performed, and uniary linear regression was used for the RV/TLC and DLCO regression equations. Results: V50, V25 and MMEF, the three indicators of both groups were positively associated with TLC, DLCO, respectively (r=0.272-0.527, P<0.05), and none was associated with KCO (P>0.05);RV/TLC in the control group was negatively associated with V25, MMEF (r=-0.322, -0.376, P<0.05); RV/TLC in the observation group was negatively associated with V50, MMEF (r=-0.336, -0.250, P<0.05). Both groups showed no significant difference (P>0.05) in TLC, FRC, RV, the three static lung function indicators, but very significant difference in RV/TLC, DLCO, KCO (P<0.001); RV/TLC, DLCO established the corresponding regression equations with V50, V25 and MMEF respectively (r=0.322-0.544, F=6.719-63.755, P<0.05) and then DLCO,
RV/TLC correction formula was acquired, i.e. corrective value=actual value±α×ΔX (α=regression coefficient,ΔX=expected-Actual). Conclusion: The elderly simple airway dysfunction affect static lung function indicators to varying degrees. It is recommended that the RV/TLC, DLCO judgment standard should adopt the corresponding correction formula to reduce false positives when assessing lung impairment in occupational disease patients with small airway dysfunction known to be caused by non-occupational factors.
