Application of rapid on-site evaluation combined with radial-endobronchial ultrasound of transbronchial cryobiopsy in the diagnosis of diffuse lung diseases
CHEN Weizhuang1, LI You1, WANG Hui1, ZHOU Yingyan1, WANG Guoan1, Shen Shimo1, Chen Jinping2, WU Shibo1, WU Hongcheng1
CHEN Weizhuang1, LI You1, WANG Hui1, ZHOU Yingyan1, WANG Guoan1, Shen Shimo1, Chen Jinping2, WU Shibo1, WU Hongcheng1
CHEN Weizhuang,LI You,WANG Hui, et al. Application of rapid on-site evaluation combined with radial-endobronchial ultrasound of transbronchial cryobiopsy in the diagnosis of diffuse lung diseases[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2022, 52(2): 132-138.
Abstract：Objective: To investigate the feasibility and safety of transbronchial cryobiopsy (TBCB) in the diagnosis of diffuse lung diseases (DLD) with assistance of Rapid On-Site Evaluation (ROSE) and Radial-endobronchial ultrasound (R-EBUS). Methods: Patients with diffuse lung disease who underwent TBCB from June 2019 to September 2021 were enrolled and their clinical characteristics, pathological types, biopsy characteristics and complications were recorded. Results: A total of 52 patients were included in the study, 20 males and 32 females, with a mean age of (54.0±13.2) years; a total of 182 cryobiopsies, (3.50±1.00) cryobiopsies per patient; the mean size of tissues was (13.69±4.72) mm2, ranging 6-30 mm2. According to the 2013 ATS/ERS classification standard for the interstitial lung diseases, there were 26 cases of known etiology (50.00%), 13 cases of idiopathic interstitial pneumonia (25.00%), 4 case of granulomatous lesions (7.69%) and 9 cases of other types (17.31%). In terms of complications, none or minimal bleeding occurred in 20 patients, mild bleeding in 21 patients, moderate bleeding in 11 patients. No severe bleeding occurred. Pneumothorax occurred in 2 patients, acute left heart failure in 1 patient and hypoxemia in 1 patient. The median post-TBCB hospital day was 6 (1.00, 6.00) days. Conclusion: The combined application of ROSE and R-EBUS in TBCB is feasible and safe in the diagnosis of DLD.
