乳腺癌RCL、TAOK1、14-3-3 zeta、ZNF706蛋白表达的临床病理意义

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摘要目的：检测RCL、TAOK1、14-3-3 zeta、ZNF706蛋白在乳腺癌中的表达，分析探讨其临床病理意义。方法：采用免疫组织化学方法检测60例乳腺癌组织切片中RCL、TAOK1、14-3-3 zeta、ZNF706蛋白的表达情况，运用数理统计的方法评价它们与病理分级、肿瘤大小、转移以及预后的关系。结果：RCL、TAOK1、14-3-3 zeta、ZNF706在乳腺癌组织中表达，且均显著强于癌旁组织（P＜0.01）；RCL的强表达与肿瘤大小、病理分级、Ki67相关（P＜0.05），TAOK1的表达与ER、HER2表达相关（P＜0.05），14-3-3 zeta的表达与ER相关（P＜0.05），ZNF706的表达与淋巴转移、ER相关（P＜0.05）。结论：RCL、TAOK1、14-3-3 zeta、ZNF706的阳性表达与乳腺癌存在关联，RCL的强表达与肿瘤大小、病理分级、Ki67相关，TAOK1的表达与ER、HER2表达相关，14-3-3 zeta的表达与ER相关，ZNF706的表达与有无淋巴转移、ER相关，测定乳腺癌组织中的RCL、TAOK1、14-3-3 zeta、ZNF706蛋白表达，有助于评判肿瘤恶性程度，预测患者预后。

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关键词 ： , RCL；TAOK1；14-3-3?zeta；ZNF706；乳腺肿瘤

Abstract：Objective: To detect the expression of RCL, TAOK1, 14-3-3 zeta and ZNF706 proteins in the breast cancer tissue, and to analyse and discuss the relationship between the expression of each protein and its clinical, as well as pathological relevance. Methods: Immunohistochemistry was used to detect the protein expression of RCL, TAOK1, 14-3-3 zeta and ZNF706 in 60 cases of breast cancer tissues, then the relationship between the expression of each protein in the cancer tissues and the tissues’ pathological grading, tumor size, metastatic status, and prognosis were evaluated by mathematic statistic methods. Results: RCL, TAOK1, 14-3-3 zeta and ZNF706 proteins were expressed in all of the breast cancer tissues, and the expression level were significantly higher than that in para-carcinoma tissues (P<0.05). The elevated expression of RCL was related to the tumor size, pathological grading and Ki67 (P<0.05). The expression of TAOK1 was related to the expression of ER and HER2 (P<0.05). The expression of 14-3-3 zeta was also related to ER (P<0.05). The expression of ZNF706 was related to lymphatic metastasis and ER (P<0.05). Conclusion: RCL, TAOK1, 14-3-3 zeta and ZNF706 proteins are high expressed in breast cancer tissues than that in normal tissues. The elevated expression of RCL is related to the tumor size, pathological grading and Ki67. The expression of TAOK1 is related to the expression of ER and HER2. The expression of 14-3-3 zeta is also related to ER. And the expression of ZNF706 is related to lymphatic metastasis and ER. The protein expression of RCL, TAOK1, 14-3-3 zeta and ZNF706 are detected in breast cancer tissues can help us determine the degree of tumor malignancy and predict the prognosis of the patients.

Key words： RCL TAOK1 14-3-3 zeta ZNF706 breast neoplasms

收稿日期: 2014-02-17

基金资助:金华市科技局科技计划项目（2011-3-073）

作者简介: 凌人（1957-），女，安徽合肥人，副主任医师

链接本文:

https://xb.wmu.edu.cn/CN/ 或 https://xb.wmu.edu.cn/CN/Y2014/V44/I11/817

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