Clinical application of 18F-FDG-PET/CT combined with magnetic resonance imaging in predicting preoperative T and N staging of colorectal cancer
ZU Liang, WANG Zufei, CHEN Weiyue,WU Xulu, XIAO Yangrui, JI Jiansong
Department of Radiology, Key Laboratory of Imaging Diagnosis and Minimally Invasive Research, Lishui Central Hospital the Affiliated Fifth Hospital of Wenzhou Medical University, Lishui 323000,China
ZU Liang,WANG Zufei,CHEN Weiyue, et al. Clinical application of 18F-FDG-PET/CT combined with magnetic resonance imaging in predicting preoperative T and N staging of colorectal cancer[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2021, 51(12): 968-973.
Abstract：Objective: To explore the clinical application value of 18F-FDG-PET/CT combined with magnetic resonance imaging (MRI) in predicting preoperative T and N staging of colorectal cancer. Methods:Patients who had surgical resection for colorectal cancer in our hospital were retrospectively enrolled from January 2015 to October 2019. All patients underwent 18F-FDG-PET/CT and MRI scans within two weeks before the operation, with postoperative pathological results taken as the gold standard. The consistency test was performed between test results and pathology, and chi-square test was used to compare the accuracy, sensitivity,and specificity of combined and single examination. Results: A total of 92 patients were enrolled in the study,including 55 males and 37 females, with the average age of (64.7±10.6)years. The study showed that the T staging results of the combined examination had a strong consistency with the pathology (Kappa value was 0.888). The accuracy (93.48%) was higher than that of PET/CT alone (69.57%), which showed statistically significant difference (P<0.001), but had no obvious advantage compared with MRI alone (P=0.090). Meanwhile,the N staging results of the combined examination had a strong consistency with the pathology (Kappa=0.804),and the accuracy (88.04%) was higher than that of MRI (67.39%) and PET/CT (75.00%), with significant difference (P=0.001 and 0.023). Furthermore, the combined examination had better, the accuracy (93.48%)and specificity (93.75%) in the diagnosis of lymph node metastasis than MRI (P=0.001 and 0.002) and PET/CT alone (P=0.037 and 0.037). Conclusion: Preoperative 18F-FDG-PET/CT combined with MRI has high diagnostic efficiency for preoperative T and N staging of colorectal cancer, especially in the evaluation of N staging and lymph node metastasis, which is of strong clinical application value.
