Effect of hysteroscopy on clinical outcome of patients with minimal endometrial lesions and failed transplantation
YE Jinbin1, SU Weijue2, FU Yanghua2, ZHAO Junzhao2
1.The Second Clinical College,Wenzhou Medical University, Wenzhou 325035, China; 2.Department of Reproductive Center, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China
YE Jinbin,SU Weijue,FU Yanghua, et al. Effect of hysteroscopy on clinical outcome of patients with minimal endometrial lesions and failed transplantation[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2021, 51(11): 902-906.
Abstract：Objective: To investigate whether hysteroscopy can improve the clinical outcome of the asymptomatic infertility with minimal endometrial lesions after the failure of in vitro fertilization-embryo transfer (IVF-ET) but before reimplantation. Methods: The clinical data of female infertility once failed in IVF-ET treated with freeze-thaw embryo transfer (FET) from July 2018 to September 2020 were retrospective analyzed.The number of cases in the control group was 225, which did not undergo hysteroscopy, while 114 cases treated with FET after hysteroscopy were in the hysteroscopy group. In the hysteroscopy group, 49 cases of all with normal uterine cavity diagnosed by hysteroscopy were in the normal group, while 65 cases treated by transcervical resection of endometrial polyp were in the polyp group. The preoperative ultrasonic results, general clinical data, clinical outcome of all cases were statistically analyzed. Results: The result of ultrasound diagnosis in 142 patients who had failed in transplantation showed that the sensitivity of ultrasound diagnosis was only 22.6%. The miscarriage rate of hysteroscopy group was lower than the control group, and the living rate in the hysteroscopy group was also higher than the control group (8.2% vs. 20.2%, P=0.040; 49.1% vs. 37.8%, P=0.045), with significant difference. There was no significant difference in clinical outcome (P>0.05) between the normal group and the polyp group, the control group and the normal group. Conclusion: For asymptomatic infertility with normal uterine cavity diagnosed by transvaginal sonography but failed in IVF-ET, hysteroscopy is recommended in diagnosis and treatment before reimplantation.
