Clinical significance of GST-π, Ki-67 and BMI in the prognosis of rectal cancer
HUANG Chongjie1, HONG Huang2, LIU Changbao1, CAO Weilan1, HUANG Yingpeng3, WANG Zhonglin1
1.Department of Anorectal Surgery, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China; 2.Department of General Surgery, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China;3.Department of Gastrointestinal Surgery, the Second Affiliated Hospital of Wenzhou Medical University,Wenzhou 325027, China
HUANG Chongjie,HONG Huang,LIU Changbao, et al. Clinical significance of GST-π, Ki-67 and BMI in the prognosis of rectal cancer[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2021, 51(11): 873-880.
Abstract：Objective: To explore the relationship between the expression of GST-π, Ki-67, BMI and the clinical biological characteristics of rectal cancer patients and its clinical significance. Methods: A retrospective collection of 308 patients with rectal cancer who underwent surgery in the Second Affiliated Hospital of Wenzhou Medical University from January 2010 to January 2013 was completed and followed up for 5 years. We analyzed the association of body mass index (BMI) and the expression of tumor markers (Ki-67, GST-π) with clinical features and pathological features of rectal cancer, as well as the correlation between BMI and Ki-67, GST-π expression and its clinical significance in rectal cancer. The relationship between the 5-year survival rate of Ki-67 high-positive patients and BMI was also analyzed. Results: The high positive expression of Ki-67 in rectal cancer is closely related to the depth of infiltration of rectal cancer, TNM staging and poor 5-year survival rate (P<0.05). Compared with the normal BMI group, the high positive expression of Ki-67 and the weight loss group had a lower 5-year survival rate for rectal cancer after surgery (P<0.05) .The positive expression of GST-π in rectal cancer tissue was significantly correlated with weight loss, lymph node metastasis, lower rectal cancer, and higher TNM staging(P<0.05). Conclusion: The combined analysis of the correlation between BMI and GST-π and Ki-67 expression level plays an important role in the clinical evalvation of the malignancy of colorectal cancer and its prognosis.
