Chromosomal analysis of patients with hyperdiploid multiple myeloma
HUANG He1, LIN Hongdou1, GUOWenjian1, LI Qian2.
1.Department of Hematology, the Second Affiliated Hospital & Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou 325027, China; 2.Department of Clinical Laboratory, the Second Affiliated Hospital & Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou 325027, China
HUANG He,LIN Hongdou,GUOWenjian, et al. Chromosomal analysis of patients with hyperdiploid multiple myeloma[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2021, 51(10): 811-816.
Abstract：Objective: To analyze the clinical features, prognosis and cytogenetic characteristics of multiple myeloma patients with hyperdiploid. Methods: Detailed data of patients diagnosed as multiple myeloma (MM) were collected from the Second Affiliated Hospital & Yuying Children’s Hospital of Wenzhou Medical University between 2009 and 2018. Bone marrow cells were cultured for a short time and karyotype was detected by routine R-banding analysis and FISH technique. Then, the karyotype characteristics of hyperdiploid patients were screened and analyzed. Furthermore, the survival curve was constructed by Mantel-Cox method, and the overall survival time of hyperdiploid and non-hyperdiploid patients was compared by Log-rank test. Results: The incidence of hyperdiploid MM patients was 22% (33/150), and the most frequent detection rate of trisomy was +5(23/33), +3(18/33), +19(17/33), +9(16/33). The gene ABL, PML, 1q21 amplification and RB1 deletion was common. However, the median survival time of hyperdiploid MM patients was 18.5 months, which had no statistical difference from that of non-hyperdiploid patients (15 months). Meanwhile, recurrent MM patients were also prone to hyperdiploid karyotype. Conclusion: The incidence of hyperdiploidy is frequent in MM, accompanied by trisomy. The diversity of gene expression is very common in the increased chromosomes, which is correlated with the prognosis.
