Abstract：Objective: To analyze the clinical manifestations, diagnosis, treatment strategies and prognosis of cervical cancer associated with pregnancy. Methods: The clinicopathological data of patients with cervical cancer associated with pregnancy, who were admitted to the First Affiliated Hospital of Wenzhou Medical University from April 2018 to June 2020, were collected and retrospectively analyzed. Results: The patients ranged in age from 30 to 35 averaged 31 years old. Among them, 4 cases were diagnosed during pregnancy, 1 case in the early pregnancy, 2 cases in the second trimester, 1 case in the third trimester and 1 case in postpartum.The most common clinical manifestation was irregular vaginal bleeding. According to FIGO 2018 staging,there was 1 case of stage IA2, 1 case of stage IB2, and 3 cases of stage IB3. Pathological type: 4 squamous cell carcinoma cases and one adenocarcinoma case. One patient received radical hysterectomy in early pregnancy,and the other 3 patients received radical hysterectomy in cesarean section at the same time. Among them, 2 patients received neoadjuvant chemotherapy (NACT) to extend the gestational age, and the gestational age at delivery was (33.0±1.5) weeks. One patient was postpartum and underwent radical trachelectomy. Three cases received chemoradiotherapy and 2 cases did postoperative chemotherapy. All 4 newborns were healthy and alive.Conclusion: The vaginal irregular bleeding during pregnancy needs timely gynecological examination to exclude cervical cancer. Cervical cancer associated with pregnancy should be combined with FIGO stage, gestational age and the patient’s fertility desire, combined with radiotherapy and chemotherapy department as well as neonatal department for multidisciplinary discussions in order to develop individualized treatment plan. Appropriate application of neoadjuvant chemotherapy is recommended to prolong gestational age, control tumor progression and improve fetal survival rate.
