对乙酰氨基酚所致急性肝损伤防治的研究进展

doi:10.3969/j.issn.2095-9400.2021.07.015

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摘要对乙酰氨基酚（APAP）作为临床上广泛使用的解热镇痛药，其肝毒性问题日益突出，已成为引起药物性急性肝损伤甚至肝衰竭的最常见药物之一。线粒体氧化应激被认为是APAP诱导肝损伤的主要细胞事件。除了线粒体氧化应激外，多种其他的细胞事件也参与了APAP所诱导的肝损伤的发生发展。笔者综述了APAP肝毒性涉及的各种细胞事件以及针对这些事件可能有效的治疗措施，有望为相关药物性肝损伤的防治提供新的线索和思路。

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	陈建彤
	卢露
	金之怡
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	汪洋

关键词 ：对乙酰氨基酚, 肝毒性, 急性肝损伤, 肝衰竭, 氧化应激

收稿日期: 2021-02-26

基金资助:温州市科技局公益技术研究医学项目（Y20180063）；国家自然科学基金资助项目（81400273）；浙江省自然科学基金资助项目（LY18H070002，LQ13H020006）；浙江省大学生科技创新活动计划暨新苗人才计划项目（2019R413080）。

通讯作者: 汪洋，副教授 E-mail: wangydh995@163.com。

作者简介: 陈建彤，硕士生，Email：996945809@qq.com。

链接本文:

https://xb.wmu.edu.cn/CN/10.3969/j.issn.2095-9400.2021.07.015 或 https://xb.wmu.edu.cn/CN/Y2021/V51/I7/593

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