GAO Zhenyan,WU Yeshun,TU Xiaoming, et al. Clinical value of serum cystatin C in evaluating the coronary lesion vessels and prognosis of coronary artery disease[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2021, 51(5): 404-408.
Abstract：Objective: To investigate the role of serum cystatin C (Cys-C) in evaluating the coronary lesion vessels and prognosis of coronary artery disease (CAD). Methods: One hundred and seventy-three patients with CAD were recruited. The baseline data were collected and the serum Cys-C levels were measured. According to the results of coronary angiography, the patients were categorized into three subgroups: the single-vessel, the doublevessel and the three-vessel. The results among the groups were compared, with the correlation and regression analysis. Results: The three-vessel group had higher uric acid and lower high density lipoprotein (HDL) levels than the single-vessel group and the double-vessel group (P=0.014, 0.044). The serum Cys-C level in the doublevessel and the three-vessel groups was significantly higher than that in the single-vessel group (P=0.016, P=0.002). Serum HDL and Cys-C levels were related to the coronary artery lesions (P=0.010, P=0.042). The serum Cys-C level was negatively correlated with left ventricular ejection fraction (LVEF) (r=-0.462, P<0.001), but positively correlated with age, high-sensitivity C-reactive protein, brain natriuretic peptide and homocysteine levels (r=0.535, P<0.001; r=0.199, P=0.009; r=0.537, P<0.001; r=0.665, P<0.001). Conclusion: The serum Cys-C level in the double-vessel and the three-vessel groups was significantly higher than that in the single-vessel group, which has clinical significance in risk stratification and prognosis evaluation.
