GE Huaizhi,CHEN Jiuzun,XU Lei, et al. Application of voxel-mirrored homotopic connectivity on fMRI in mild cognitive impairment[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2021, 51(5): 369-374.
Abstract：Objective: To explore the abnormal changes of brain functional connectivity in patients with mild cognitive impairment (MCI) by resting-state functional magnetic resonance imaging (rs-fMRI) using voxelmirror homotopic connectivity (VMHC) and seed-based functional connectivity (FC). Methods: Twenty-nine patients with MCI (MCI group) and twenty-nine healthy controls with similar gender, age and education level(HC group) were enrolled. All participants in both groups underwent the analysis of related mental scales and 3.0T MRI scan. The difference in functional connectivity between the two groups was analyzed by VMHC and FC.The difference in VMHC value between the two groups was compared by independent sample t-test, and different brain regions were used as seeds to analyze the differences between them with the whole brain. Results: Compared with HC group, MCI group had higher VMHC value of bilateral superior temporal gyrus (41 differences voxels,t=4.264, P<0.05). The functional connectivity between left superior temporal gyrus and right fusiform gyrus,left middle frontal gyrus and right middle frontal gyrus were increased in MCI group (P<0.05), and functional connectivity between right superior temporal gyrus and left fusiform gyrus, left middle temporal gyrus, right inferior frontal gyrus, left cuneiform lobe and left middle occipital gyrus were increased (P<0.05). Conclusion:The homotopic connectivity of bilateral superior temporal gyrus was increased in patients with MCI at rest,which suggested impairment of sensory language center and compensatory enhancement of contralateral centers
in MCI.
