HOU Qiuying,LIU Jue,ZHANG Xu, et al. The effectiveness of vitamin D on respiratory distress syndrome of premature infants[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2021, 51(4): 319-322.
Abstract：Objective: To study the effectiveness of vitamin D on neonatal respiratory distress syndrome (NRDS). Methods: Totally 82 cases of premature infants (28 weeks < gestational age < 34 weeks) with NRDS from Jiaxing Second Hospital from March 2017 to March 2019 were selected as NRDS group for prospective study, which was further divided randomly as subgroup (routine treatment) and subgroup 2 (routine treatment plus oral vitamin D 1 000 IU/d). Another 84 preterm infants without NRDS in the same period were selected as the control group for routine treatment only. Vitamin D level was compared at birth and its effect on NRDS in two subgroups were evaluated. Results: Vitamin D level in NRDS group was significantly lower than that in the control group (P<0.05). The NRDS group had lower Downes respiratory distress score and PaCO2 level, shorter hospital stay and lower complication rate (P<0.05). Conclusion: Vitamin D is generally deficient in preterm infants, especially in NRDS. 1 000 IU/d vitamin D as an adjuvant treatment can significantly reduce the disease severity, oxygen use time, hospital stay and complications of NRDS in preterm infants.
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