Promotion of romotes skeletal muscle function recovery in hysterectomy patients by Shenmai injection
ZHU Meizhen1, PAN Yafei2, CHEN Lei1, WANG Liangrong1, LIN Li’na1
1.Department of Anesthesiology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325015, China; 2.Department of Anesthesiology, Cancer Hospital of the University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou 310000, China
ZHU Meizhen,PAN Yafei,CHEN Lei, et al. Promotion of romotes skeletal muscle function recovery in hysterectomy patients by Shenmai injection[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2021, 51(4): 315-318.
Abstract：Objective: To investigate the effect of Shenmai injection pretreatment on the levels of cytokines in abdominal drainage and skeletal muscle function in patients undergoing laparoscopic hysterectomy. Methods: Sixty-six patients undergoing laparoscopic hysterectomy were randomly divided as the control group (C group) and the Shenmai group (SM group). The patients in SM group received intravenous administration of Shenmai injection 0.6 mL/kg before skin incision, while the same amount of saline was given instead in C Group. The grip strength, muscle endurance, and inflammatory cytokines levels in abdominal drainage fluid were measured before
surgery as baselines and 4 h, 1, 2 days post-operation as well. The occurrence of nausea, vomiting and other adverse events were also documented. Results: Compared with C group, the declines in grip strength and muscle endurance in SM group were significantly attenuated in each time point (P<0.05). However, grip strength and muscle endurance were decreased in both groups, compared with baseline values (P<0.05). The levels of IL-6 and TNF-α in the abdominal drainage fluid of SM group at 4 hours post-operation were significantly lower than those of group C (P<0.05), and the level of IL-6 in the drainage fluid was negatively correlated with grip work (P<0.05). There was no significant difference in adverse events between the the groups (P>0.05). Conclusion: Pretreatment with Shenmai injection 0.6 mL/kg could reduce the production of inflammatory cytokines and thus promote the recovery of skeletal muscle function in patients undergoing laparoscopic hysterectomy.
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