RUAN Xiaojiao,JI Ling,ZHU Hengliang, et al. Analysis of clinical features and surgery treatment of 7 cases of primary liver sarcomatoid carcinoma[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2014, 44(10): 752-755.
Abstract：Objective: To explore the clinical and pathological features of primary liver sarcomatoid carcinoma and to discuss its diagnosis, the operative method and prognosis. Methods: The clinical data of 7 patients with pathologically proven sarcomatoid carcinoma of the liver were retrospectively reviewed in our hospital from February 2004. Results: Three cases showed right upper abdomen pain, abdomen distension in 1 case, 1 case of anorexia and fatigue, 2 cases were asymptomatic. The CT appearances of sarcomatoid carcinoma had both characteristics of hepatic cancer and carcinoma CT signs could show malignant characlteristics of lesion.Varied degrees of contrast enhancement could be visualized. All the patients were undergone surgery. The tumor was composition with cancer and sarcoma-like areas, and the tumor cells of sarcomatoid areas were very complex.Immunohistochemical positive for CK (7), EMA (5), MSA (1), CK7 (2), HepPar-1 (3) and Vimentin (6), DES (1). The length of follow-up ranged from 17 days to 35 months during which time 2 patients with disease free, 2 survived as tumer carriers and 3 patients died. Conclusion: Liver sarcomatoid carcinoma is a kind of extremely rare malignant tumor, with untypical clinical symptoms, non-specific imaging feature, tumor cells with complex and diverse pathological features, diagnosed according to immunohistochemistry. Surgical resection is the main treatment, insensitive to radiotherapy and chemotherapy,with worse prognosis.
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