XUAN Xuan,WU Lingjian,LI Bingxu. Obserration on the effect of narrow-band ultraviolet b combined with desloratadine in the treatment of generalized eczema and dermatitis[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2014, 44(10): 737-739.
Abstract：Objective: To evaluate the clinical efficacy and safety of narrow-band ultraviolet b combined with desloratadine in the treatment of generalized eczema and dermatitis. Methods: Non-randomized concurrent control trial was used to assign 114 patients in UV-treatment group (n=57) and glucocorticoid-treatment group (n=57). Patients in UV-treatment group received the therapy of narrow-band ultraviolet b combined with oral desloratadine. Patients in glucocorticoid-treatment group were topically applied with mometasone furoate ointment combined with oral desloratadine. In UV-treatment group, symptom/sign scores were evaluated at the 2th, 4th and 8th week’s end of the treatment. In glucocorticoid-treatment group, symptom/sign scores were evaluated at the 2th and 4th week’s end of the treatment. Scores and effective rates were observed after the treatment. Results: After 2 weeks of treatment, the median score of glucocorticoid-treatment group (3) and UV-treatment group (2) had significant difference (P<0.05); the efficient rate of UV-treatment group (12.3%) and hormones-treatment group (38.6%) had significant difference (P<0.05). After 4 weeks of treatment, the median score of glucocorticoid-treatment group (5) and UV-treatment group (4) had no significant difference (P>0.05); the efficient rate of UV-treatment group (59.6%) and glucocorticoid-treatment group (56.1%) had no significant difference (P>0.05). In UV-treatment group, the median score had significant difference at the 2th (2), 4th (4) and 8th (6) week’s end of the treatment; the efficient rate had significant difference at the 2th (12.3%), 4th (59.6%) and 8th (84.2%) week’s end of the treatment. Conclusion: The therapy of narrow-band ultraviolet b is safe and effective in the treatment of patients with generalized eczema and dermatitis.
