A comparative study of CD31 expression level and image spatial heterogeneity between benign and malignant pulmonary nodules
HONG Junjie1, LIU Bole1, CHEN Yao2, TANG Kun1, XUE Beihui1, WU Sunjie1, ZHENG Xiangwu1
1.Department of Radiology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325015, China; 2.Department of Pathology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325015, China
HONG Junjie,LIU Bole,CHEN Yao, et al. A comparative study of CD31 expression level and image spatial heterogeneity between benign and malignant pulmonary nodules[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2021, 51(2): 142-145.
Abstract：Objective: To analyze the spatial heterogeneity of microvascular density (MVD) in benign and malignant pulmonary nodules based on CD31 expression level. Methods: Thirty-five cases of paraffin tissue specimens were collected after wedges resection of pulmonary nodules, including 7 cases of squamous cell carcinoma, 23 cases of adenocarcinoma and 5 cases of inflammatory nodules. Immunohistochemistry was used to detect the expression level of CD31, a microvascular marker in the proximal and distal pulmonary nodules. Paired t-test and independent sample t-test were used to analyze the difference of CD31 expression level between intragroup
and inter-group. Results: CD31 expression in the proximal/distal part of the 30 malignant nodules was 19.2±8.6 and 13.3±6.8, respectively, with significant difference (P<0.05). The CD31 expression in the proximal/distal part of 5 benign nodules was 28.2±10.0 and 26.8±3.0, respectively, without statistical difference (P>0.05).The comparison between benign and malignant groups showed that the expression of CD31 at the distal part of benign nodules was higher than that of malignant nodules (P<0.05). No significant difference was found in the expression of CD31 at the proximal part of benign and malignant nodules (P>0.05). Conclusion: Based on CD31
expression level, difference exists in MVD of proximal/distal part between benign and malignant pulmonary nodules, which provides pathological basis for the spatial heterogeneity of benign/malignant pulmonary nodules.
