心踝血管指数、年龄及其交互作用与颈动脉粥样硬化的关联分析#br#

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摘要目的：探索心踝血管指数（CAVI）、年龄及其交互作用与颈动脉粥样硬化早期识别的关联性。方法：对2010年5月1日至2011年9月30日，在安徽医科大学第一附属医院临床体检中心进行常规体检的328名受试者，进行CAVI的重复测定和颈动脉超声检测，多元广义线性模型探索CAVI、年龄及其交互作用与颈动脉硬化的关联性。结果：高、中、低CAVI人群颈动脉粥样硬化的发生率分别为90.9%、57.0%和19.8%，校正年龄、性别、体质量指数（BMI）、低密度脂蛋白胆固醇、空腹血糖等潜在的混杂因素后，与CAVI最低组比较，中等和较高CAVI水平者发生颈动脉粥样硬化的风险分别是对照组的2.2倍（OR:2.2，95%CI:1.0～4.9）和4.4倍（OR:4.4，95%CI:1.5～13.3）；与低年龄组比较，中、高年龄组发生颈动脉粥样硬化的风险分别是对照组的8.1倍（OR:8.1，95%CI:3.5～18.8）和52.3倍（OR:52.3， 95%CI:14.9～183.5），CAVI水平及年龄均与颈动脉粥样硬化的发生风险存在显著的正相关关系（趋势性检验P＜0.001）；与低龄且低CAVI人群比较，低龄高CAVI、高龄低CAVI和高龄高CAVI人群颈动脉粥样硬化的发生风险分别是对照组的6.6、17.3和57.1倍。结论：CAVI是颈动脉硬化的独立危险因素，在预测颈动脉粥样硬化发生风险方面与年龄间存在协同效应。

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	黄系1
	李萍1
	张芹1
	诸葛张明1
	胡华青2
	崔寰3
	阮积晨1
	毛广运4

关键词 ：心踝血管指数, 颈动脉疾病, 心血管疾病, 横断面研究

Abstract：Objective: To explore the correlation between arteriosclerosis early identification and cardio-ankle vascular index (CAVI), age and their interaction. Methods: A cross-sectional study was conducted to explore this association in a Chinese population consisting of 328 participants enrolled from the ordinary medical checkup population in the 1st affiliated hospital of Anhui Medical University. CAVI was measured in duplicate and carotid ultrasound detection was performed in a quiet environment by well-trained physicians. Generalized linear models were conducted to assess the correlation. Results: Prevalence of carotid arteriosclerosis for participants with high, medium and low CAVI score were 90.9%, 57.0% and 19.8%, respectively. After adjusted for the potential confounding factors such as age, gender, body mass index (BMI), low density lipoprotein cholesterol (LDL), fasting plasma glucose (FPG), blood pressure (BP), creatinine, education, occupation, psychological tension, cigarette smoking and alcohol drinking, CAVI positively associated with the risk for carotid arteriosclerosis. Compared with participants in the lowest tertile of CAVI (5.15~7.40), those in the medium (7.41~8.65) and highest (8.66~13.60) had the OR (95% CI) of 2.2 (1.0, 4.9) and 4.4 (1.5, 13.3) for developing carotid arteriosclerosis (P=0.007). Compared with low age groups, the risks of future carotid arteriosclerosis for participants with medium and high age increased 7.1 and 51.3 folds, respectively. CAVI and age were all positively associated with the future carotid arteriosclerosis risk (Trend test P<0.001). Compared to subjects with low age and low CAVI, the risks of future carotid arteriosclerosis for participants with low age and high CAVI, high age and low CAVI, high age and high CAVI increased 6.6, 17.3 and 57.1 folds, respectively. Conclusion: CAVI is an independent risk factor of carotid arteriosclerosis, can be used for the prediction of future carotid arteriosclerosis developing and has a statistical significantly interaction with age in predicting the future risk of carotid arteriosclerosis.

Key words： cardio-ankle vascular index carotid artery disease cardiovascular disease cross-sectional study

收稿日期: 2013-09-18

基金资助:浙江省自然科学基金资助项目（Y2110454）；温州市科技局面上项目（y20090026）；温州医学院学生科研立项课题（WYX201201022）。

通讯作者: 毛广运，副教授，硕士生导师，Email: mgy@wmu.edu.cn。

作者简介: 黄系(1993-)，女，浙江温州人，本科生。

链接本文:

https://xb.wmu.edu.cn/CN/ 或 https://xb.wmu.edu.cn/CN/Y2014/V44/I10/727

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