An investigation into the complications of warfarin anticoagulant therapy and its influencing factors in patients with cardiac mechanical valve replacement
SHI Huoshun1, SHAO Guofeng1, ZHAO Shunying2, HU Xiaoyan2.
1.Department of Cardiothoracic Surgery, Ningbo Medical Treatment Centre of Lihuili Hospital, Ningbo 315041, China; 2.Department of Cardiac Care Unit, Ningbo Medical Treatment Centre of Lihuili Hospital, Ningbo 315041, China
SHI Huoshun,SHAO Guofeng,ZHAO Shunying, et al. An investigation into the complications of warfarin anticoagulant therapy and its influencing factors in patients with cardiac mechanical valve replacement[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2021, 51(1): 62-65.
Abstract：Objective: To investigate the influencing factors of warfarin-related complications in mechanical
valve patients, so as to understand the factors that may influence patients' anticoagulation compliance. Methods: Patients who had mechanical valve replacement in Ningbo Medical Treatment Centre of Lihuili Hospital from January to December 2012 were enrolled in this investigation. The questionnaire, which included general information of patients, anticoagulant condition, coagulation function and other indicators, was completed by all subjects mainly via telephone visits and outpatient follow-up. Chi-square test was used for categorical variables, and logistic regression model for multivariate analysis. Results: There was statistical difference in anticoagulant compliance and atrial fibrillation (AF) between two groups of anticoagulation complications (P<0.05), while there’s no significant difference between the two groups in the type of valve replacement, patient’s age, education, history of cerebral infarction, history of tobacco and alcohol and other long-term drug history (P>0.05). Multivariate logistic regression showed that AF and anticoagulation compliance were significantly associated with anticoagulant complications, with OR values being 2.570 and 4.628 respectively. Conclusion: Poor compliance with administration of warfarin and atrial fibrillation are independent risk factors for anticoagulation complications after mechanical valve replacement.
