Epidemiological characteristics of human adenovirus in hospitalized children with lower respiratory tract infection and its correlation with meteorological factors in Wenzhou
1.Department of Children’s Respiration Disease, the Second Affiliated Hospital & Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou 325027,
China; 2.Wenzhou Meteorological Bureau, Wenzhou 325027, China; 3.Department of Clinical Research Center, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China
WEN Shunhang,LIN Zupan,ZHOU Bigao, et al. Epidemiological characteristics of human adenovirus in hospitalized children with lower respiratory tract infection and its correlation with meteorological factors in Wenzhou[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2021, 51(1): 25-29.
Abstract：Objective: To study the epidemiological characteristics of human adenovirus (HAdV) infection in lower respiratory tract among hospitalized children in Wenzhou and its correlation with meteorological factors. Methods: A retrospective analysis was made on respiratory virus antigen detection data of children admitted to the Second Affiliated Hospital & Yuying Children’s Hospital of Wenzhou Medical University between Jan 2008 and Dec 2017 due to acute lower respiratory tract infection, and the epidemiological characteristics of HAdV infection were analyzed. Meanwhile, meteorological data of Wenzhou from Jan 2008 to Dec 2017 were collected, including average temperature per ten-day period, average humidity, total rainfall, rainfall days and average wind speed. Generalized additive models (GAM) were used to conduct univariate and multivariate regression analyses to explore the correlation between HAdV prevalence and meteorological factors. Results: Of 89 898 nasopharyngeal aspirates and/or sputum specimens tested for respiratory virus antigen between Jan 2008 and Dec 2017, a total of 1 974 (2.2%) cases tested positive for HAdV infection, of which 339 cases were <1 year old, 615 cases were 1-3 years old, 597 cases were 3-5 years old, and 423 cases were aged 5-18 years. The number and rate of HAdV detection in children peaked between May and July. Based on GAM moder, HAdV detection rate
increased with the temperature getting higher (P=0.015) and the wind speed getting slower (P=0.003). With the increase of wind speed, the decline scale of detection rate reduced gradually. Conclusion: HAdV infection peaked in late spring and early summer among hospitalized children with lower respiratory tract infection in Wenzhou. Temperature and wind speed are the main meteorological factors related to the prevalence of HAdV.
