Association between insulin-like growth factor-2 in cord vein and macrosomia
WANG Dan1, YAN Ya’na1,FAN Shuli2, CAI Caiping2, WANG Qiu1
1.Department of Pediatrics, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325015, China; 2.Department of Obstetrics, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325015, China
WANG Dan,YAN Ya’na,FAN Shuli, et al. Association between insulin-like growth factor-2 in cord vein and macrosomia[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2021, 51(1): 8-12，18.
Abstract：Objective: To evaluate the serum concentration of insulin-like growth factor-2 (IGF-2) in cord vein and to assess its relationship with macrosomia. Methods: Totally 61 macrosomia (MAC) and 60 normal birth weight (NBW) term infants, born in the First Affiliated Hospital of Wenzhou Medical University from
January 2018 to December 2019 were enrolled in this study. The serum IGF-2 concentration in cord vein was detected. Pearson or Spearman correlation analysis was used to assess the relationship between IGF-2 and growth parameters of the newborn. Results: The serum concentrations of IGF-2 in cord vein were (221.92±29.97)ng/mL and (169.69±14.53)ng/mL in MAC group and NBW group respectively, with significant difference (P<0.001). Newborns of gestational diabetes mellitus (GDM) versus euglycemic mothers had an elevated level of cord vein IGF-2 (GDM-MAC vs. nGDM-MAC=229.71 ng/mL vs. 214.18 ng/mL, P=0.046; GDM-NBW vs. nGDM-NBW=175.69 ng/mL vs. 161.48 ng/mL, P<0.001). Correlation analysis showed that cord vein IGF-2 was positively related to birth weight, birth length, and ponderal index (PI) (r=0.678, 0.566, 0.600, P<0.001). The concentration of IGF-2 was also related to gestational age (r=0.273, P=0.002). However, there was no significant correlation between IGF-2 level and newborn gender, maternal age, maternal higher education or primiparity (P>0.05). Conclusion: IGF-2 level in cord vein of newborn is affected by maternal gestational diabetes mellitus and gestational age. Meanwhile, IGF-2 is correlated to fetal growth and its high level may play an important role in the occurrence of macrosomia.
