Investigation and analysis of RBC-irregular antibodies in hospitalized patients
CHEN Bile1, CAI Xuejiao1, YE Yincai1, LIN Shuangnyu1, ZHUO Shenglin2, XIE Zuoting1
1.Department of Blood Transfusion,the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325015, China; 2.Department of Blood Transfusion, Yongjia County People’s Hospital, Wenzhou 325100, China
CHEN Bile,CAI Xuejiao,YE Yincai, et al. Investigation and analysis of RBC-irregular antibodies in hospitalized patients[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2020, 50(11): 915-918.
Abstract：Objective: To investigate and analyze the positive rate, distribution characteristics, specificity and immunoglobulin types of RBC-irregular antibodies in hospitalized patients. Methods: Samples of all patients in our hospital between Nov. 2017 and Oct. 2019 were collected, with irregular samples of erythrocyte blood groups screened for a statistical analysis of positive antibodies, the positive rate, distribution characteristics,specificity and immunoglobulin types of antibodies. Results: Total positive rate of RBC-irregular antibodies in hospitalized patients was 0.29%(834/287 030); the positive rate of antibody in male patients and female patients was 0.20% and 0.38% respectively. There was statistically difference between groups (P<0.05). RBC-irregular antibodies distribution had the following characteristics: the antibody-positive composition ratio of female patients was 66.99%(558/834), while that of male patients was 33.01%(276/834). The proportion of antibody-positive was 72.22%(403/588) in women with history of pregnancy but no history of blood transfusion, and that was 5.38%(30/588) in women with no history of pregnancy but history of blood transfusion; the antibody-positive ratio of female patients with history of both pregnancy and blood transfusion was 19.35%(108/588), while the antibodypositive ratio of female patients without history of either pregnancy or blood transfusion was 3.05%(17/588).RBC-irregular antibodies specificity showed that 54.80%(457/834) of antibody specificity could be determined,of which the Rh blood group system had the highest proportion of anti-E antibodies, accounting for 27.58%.Immunoglobulin types of RBC-irregular antibodies were mainly IgG antibodies, accounting for 72.90%(632/834).Conclusion: In patients with RBC-irregular antibodies positive in this hospital were mainly female patients with pregnancy history, and the specificity of irregular antibodies was most commonly IgG anti-E antibodies.
