LYU Wei,ZHU Cheng,ZHENG Ke, et al. Relationship between serum prolactin and cognitive function in patients with first episode schizophrenia[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2020, 50(8): 666-669.
Abstract：Objective: To compare the levels of serum prolactin and cognitive function between first episode schizophrenic patients and healthy controls, and further analyze the relationship between cognitive function and homocysteine in schizophrenic patients. Methods: Eighty first episode schizophrenic patients and eighty normal persons were selected as case group and control group from January to December 2018 in the Affiliated Kangning Hospital of Wenzhou Medical University. After entering the group, the plasma level of prolactin and the score of Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) were measured in schizophrenic patients and healthy controls. The collected data were analyzed by correlation analysis and stepwise regression analysis. Results: The serum level of prolactin in schizophrenic patients was significantly higher than that in healthy controls, while the total score of RBANS and its factor scores in schizophrenic patients were significantly lower than that in healthy controls (P<0.05). The serum prolactin level was negatively correlated with the total score of RBANS, the factor score of visual span and speech function (r=-0.423, -0.271, -0.352, P<0.05), but not with the factor score of attention, immediate memory and delayed memory (P>0.05). The serum prolactin level entered the regression equation with RBANS total score, visual span and speech function factors score as dependent variables, that could explain 25.70%, 14.70% and 19.60% of the changes of RBANS total score, visual span and speech function factors score respectively (P<0.05). Conclusion: Patients with schizophrenia have elevated serum prolactin levels and cognitive impairment. The abnormity of serum prolactin in patients with schizophrenia is associated with cognitive impairment.
