Risk factors of abdominal Henoch-Schönlein purpura in children
WENG Shengliang1, ZHANG Youla2
1.Department of Pediatrics, the Fifth Hospital of Jinhua, Jinhua 321000, China; 2.Department of Dermatology, the Fifth Hospital of Jinhua, Jinhua 321000, China
WENG Shengliang,ZHANG Youla. Risk factors of abdominal Henoch-Schönlein purpura in children[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2020, 50(8): 657-661.
Abstract：Objective: To investigate the risk factors of children with abdominal Henoch-Schönlein purpura (HSP) and to provide the predictors for early clinical diagnosis and treatment. Methods: Ninety-eight children with HSP from the Fifth Hospital of Jinhua during January 2011 and December 2018 were collected, which included
50 abdominal HSP and 48 skin-type HSP. The clinical characteristics and laboratory indicators of those children
between two groups were compared. The risk factors of HSP in children were analyzed by logistic regression analysis. Results: The incidence of upper respiratory tract infection in children with abdominal HSP was significantly higher than that in children with skin HSP (P<0.05). The laboratory indicators of white blood cell count, neutrophil count, C-reactive protein, D-dimer in children with abdominal HSP were significantly higher than those of skin-type HSP (P<0.05). There were no significant differences between the two groups (P>0.05) in other indicators such as gender, age, season of onset, hospitalization days, hemoglobin, platelet count, serum potassium, alanine aminotransferase, aspartate aminotransferase, serum albumin, ESR, complement C3, C4, IgA, prothrombin time and activated partial prothrombin kinase time were not significantly different between the two groups (P>0.05). Logistic regression analysis showed that upper respiratory tract infection (OR=3.54, 95%CI=1.29-9.75, P=0.014) and high D-dimer (OR=4.23, 95%CI=1.28-13.96, P=0.018) were independent risk factors for HSP in children. Conclusion: Children of HSP with risk factors such as upper respiratory tract infection and high D-dimer should be intervened early and treated properly to prevent complications.
