The significance of serum retinol binding protein in patients with nonalcoholic fatty liver disease
PAN Jie1, GAO Min2, JI Guofei3
1.Department of General Surgery, Huzhou Central Hospital, Huzhou 313000, China; 2.Department of Clinical Laboratory, Huzhou Central Hospital, Huzhou 313000, China; 3.Department of Ultrasonography, Huzhou Central Hospital, Huzhou 313000, China
PAN Jie,GAO Min,JI Guofei. The significance of serum retinol binding protein in patients with nonalcoholic fatty liver disease[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2020, 50(8): 642-646.
Abstract：Objective: To explore the possible association between serum retinol binding protein (RBP) and nonalcoholic fatty liver disease (NAFLD). Methods: From October 2017 to August 2018 in Huzhou Central Hospital, 167 patients with NAFLD diagnosed by abdominal ultrasonography and 141 healthy controls were enrolled in the study and their fasting serum RBP levels and other clinical and laboratory parameters were measured. Results: NAFLD patients had significantly higher serum RBP levels than controls (P<0.05). Serum RBP level was significantly and positively correlated with parameters of metabolic syndrome (BMI, fasting blood glucose), inflammation indexes (sialic acid, hypersensitive C-reactive protein), and markers of hepatocellular damage (alanine aminotransferase, alanine aminotransferase) (P<0.05). Subgroup (obesity, triglycerides, fasting blood glucose) analysis showed that serum RBP level was significantly increased in NAFLD subjects with individual components of obesity, hypertriglyceridaemia, and hyperglycaemia. Multivariate logistic regression analysis showed that the increase of RBP level (OR=2.580, 95%CI=1.718-3.356, P<0.001) was an independent risk factor for the occurrence and development of NAFLD. Conclusion: Serum RBP level is closely related to NAFLD.
