LIN Jie,TANG Kun,YIN Weiwei, et al. The role of dual time point PET/CT imaging in diagnosis of solitary pulmonary nodule with low metabolism[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2014, 44(9): 704-.
Abstract：Objective: To evaluate the role of dual time point 18F-FDG PET/CT imaging in diagnosis of solitary pulmonary nodule (SPN) with low metabolism. Methods: During August 2011 to June 2013, forty-five patients confirmed with SPN and SUVmax≤2.5 at early PET/CT imaging were retrospectively analysed (male 27, female 18, mean age 59.71±11.42 years). All patients were performed with early and delayed PET/CT imaging at 60 min and 120 min after intravenous injection respectively. The eraly and delayed maximum standardized uptake value (SUVmax) of PET/CT imaging were measured and the change of SUVmax (△SUVmax) was calculated. The sensitivity, specificity and accuracy were calculated using the △SUVmax≥0 as diagnostic positive standard, and the receiver operating characteristic (ROC) curve was used to evaluate the diagnostic vale of △SUVmax for low metabolic SPN. Results: The differences in average SUVmax of early and delayed imaging between benign and malignant nodules had no statisticly significance (t=0.193, P=0.848, t=1.452, P=0.154). There was significant difference in mean △SUVmax between malignant and benign lesions (t=2.738, P=0.009). The sensitivity, specificity, accuracy, positive predictive value and negative predictive value were 87.88%, 66.67%, 82.22%, 87.88% and 66.67% respectively with △SUVmax≥0 as diagnostic positive standard. The area under ROC curve was 0.861 according to the △SUVmax. Conclusion: The dual time point PET/CT imaging is useful for differentiating solitary pulmonary nodules with early SUVmax≤2.5 and without specific morphological characteristics.
