Clinical significance of monitoring serum NO and AGEs in patients with asymptomatic type 2 diabetic peripheral neuropathy
XU Yingying1, HUANG Xingyou2, WEI Zhili3, WANG Chenfang1, LIU Jingjing1, PAN Weili1
Department of Endocrinology, Rheumatology and Nephrology, the Third Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine, Hangzhou 310005, China; 2.Inspection Division of the Third Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine, Hangzhou 310005, China; 3.the Third Clinical Medical College of Zhejiang University of Traditional Chinese Medicine, Hangzhou 310014, China
XU Yingying,HUANG Xingyou,WEI Zhili, et al. Clinical significance of monitoring serum NO and AGEs in patients with asymptomatic type 2 diabetic peripheral neuropathy[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2020, 50(5): 411-414,418.
Abstract： Objective: To study the clinical significance of monitoring nitric oxide (NO) and advanced glycation end-products (AGEs) in asymptomatic type 2 diabetes mellitus (T2DM) peripheral neuropathy (DPN). Methods: From December 2015 to December 2018, a total of 80 inpatients with T2DM from the Third Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine were selected. 60 patients were diagnosed as DPN by measuring vibration perception threshold (VPT) and nerve conduction velocity (NCV), and the remaining 20 patients were in simple T2DM group. And then 60 DPN patients were further divided into symptomatic DPN group (n=29) and asymptomatic DPN group (n=31) by the presence or absence of limb numbness, burning sensation, pain and other symptoms. The levels of fasting plasma glucose (FPG), 2-hour postprandial plasma glucose (PPG), glycosylated hemoglobin (HbA1c), triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein cholesterol (HDL-c), apolipoprotein a (APOa) and apolipoprotein b (APOb) were compared among the three groups, and the results of NO and AGEs were also compared among the three groups. Results: The levels of FPG, PPG and HbA1c in symptomatic DPN group were significantly higher than those in asymptomatic DPN group and simple T2DM group (P<0.01). The levels of FPG, PPG, and HbA1c in asymptomatic DPN group were higher than those in simple T2DM group (P<0.05). There were no significant differences in the levels of TG, TC, LDL-c, HDL-c, APOa and APOb among the three groups (P>0.05). Compared with simple T2DM group, in two DPN groups the levels of serum NO were significantly decreased and the levels of serum AGEs were significantly increased (P<0.01); the levels of serum NO and AGEs were significantly different between the two DPN groups (P<0.01). Conclusion: The incidence of early asymptomatic DPN is high in clinical practice. NO and AGEs are important biological signals and effector molecules. Early detection of them will help to understand the degree of neuropathy. Controlling blood glucose is of great clinical importance in reducing the incidence of DPN.
