LINC00460在肾透明细胞癌中的表达及其临床意义

doi:10.3969/j.issn.2095-9400.2020.05.009

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摘要目的：探讨LINC00460在人ccRCC中表达的临床意义。方法：通过TCGA数据库下载611例人 ccRCC的转录组数据以及相应的患者的临床信息，然后提取LINC00460在人ccRCC中的表达谱数据。分析 LINC00460在人ccRCC以及癌旁组织中的表达，并进一步分析其与患者的临床病理学参数及预后的相关性。结果：ccRCC组织中LINC00460表达水平均较癌旁组织明显升高，差异有统计学意义（ P ＜0.05）。结合患者临床病理学相关参数分析显示，LINC00460高表达与更高的病理学分期（I/II期 vs. III/IV期， OR =2.82， 95% CI =1.96～4.07， P ＜0.001）、T分期（T1/2 vs. T3/4， OR =2.65，95% CI =1.84～3.84， P ＜0.001）、N分期（N0 vs. N1， OR =7.80，95% CI =2.12～50.40， P =0.007）、M分期（M0 vs. M1， OR =3.22，95% CI =1.91～5.61，P ＜0.001）和组织学分级（G1/2 vs. G3/4， OR =2.08，95% CI =1.46～2.95， P ＜0.001）相关。Cox回归分析显示，LINC00460是影响患者总生存预后的独立因素（ HR =1.05，95% CI =1.01～1.10， P =0.010）。结论：人 ccRCC组织中LINC00460的表达水平较癌旁组织明显升高，其高表达与患者的总生存预后更差相关，因此， LINC00460可能是预测肾癌患者预后的生物标志物。

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	王辰飞
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	苏明

关键词 ： , 肾透明细胞癌；LINC00460；TCGA数据库

Abstract：Objective: To explore the expression and clinical significance of LINC00460 in clear cell renal cell carcinoma (ccRCC). Methods: Gene expression profiles of 611 ccRCC patients and their clinical data were downloaded from TCGA database. We studied the expression of LINC00460 in pairs of ccRCC tissues and matched non-cancerous adjacent tissues, and then analyzed the relationship between expression of LINC00460 and clinical parameters and prognosis of patients. Results: Over-expression of LINC00460 was found more in ccRCC tissues than non-cancerous adjacent tissues (P<0.05). The increased expression of LINC00460 was significantly associated with high pathological stage (I/II vs. III/IV, OR=2.82, 95%CI=1.96-4.07, P<0.001), T stage (T1/2 vs. T3/4, OR=2.65, 95%CI=1.84-3.84, P<0.001), N stage (N0 vs. N1, OR=7.80, 95%CI=2.12-50.40, P=0.007), M stage (M0 vs. M1, OR=3.22, 95%CI=1.91-5.61, P<0.001) and histological grade (G1/2 vs. G3/4, OR=2.08, 95%CI=1.46-2.95, P<0.001). Cox regression analysis showed that LINC00460 was an independent factor in predicting the overall survival of ccRCC patients (HR=1.05, 95%CI=1.01-1.10, P=0.010). Conclusion: LINC00460 have over-expression in ccRCC tissues than non-cancerous adjacent tissues. Patients of high LINC00460 expression have worse prognosis than patients of low LINC00460. Therefore, LINC00460 could be a biomarker for the prognosis of ccRCC patients.

Key words： clear cell renal cell carcinoma LINC00460 TCGA database

收稿日期: 2019-07-23

通讯作者: 苏明，研究员，硕士生导师，Email：m.su@neu.edu。

作者简介: 王辰飞（1995-），男，山西高平人，硕士生。

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https://xb.wmu.edu.cn/CN/10.3969/j.issn.2095-9400.2020.05.009 或 https://xb.wmu.edu.cn/CN/Y2020/V50/I5/395

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