ROC curve-based study of the screening criteria for the unrelated hematopoietic stem cell donors
TU Xiaolian1, YANG Ting2, PENG Fang2, SUN Yudan3, ZHANG Guohua4, DING Na’ni2
1.Renji College, Wenzhou Medical University, Wenzhou 325035, China; 2.School of Public Health and Management, Wenzhou Medical University, Wenzhou 325035, China; 3.Wenzhou Daily Newspaper Group, Wenzhou 325000, China; 4.School of Psychiatry, Wenzhou Medical University, Wenzhou 325035, China
TU Xiaolian,YANG Ting,PENG Fang, et al. ROC curve-based study of the screening criteria for the unrelated hematopoietic stem cell donors[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2020, 50(4): 323-327.
Abstract：Objective: To determine the criteria for screening the unrelated hematopoietic stem cell donors based on the receiver operating characteristic curve (ROC curve). Methods: A questionnaire survey was conducted between 2007 and 2018 in Wenzhou City to collect information from 40 donors who donated hematopoietic stem cells and 166 potential donors in order to construct a ROC curve between donation cognition, donation willingness and donation attitude. Results: A joint screening method integrating the degree of donation cognition, donation willingness and donation attitude were used. The area under the ROC curve was 0.87 (95%CI: 0.81-0.93), with sensitivity being 70.00% and specificity 90.96%. The consistent rate was 86.89% and the Youden index was 0.61. Conclusion: To promote the possibility of donation and reduce the refusal rate, it is helpful to enhance the awareness of unrelated hematopoietic stem cell donors, while increasing their willingness and attitude towards hematopoietic stem cell donation.
